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| Study on single drug toxicity of Euphorbia fischeriana Steud Powder and Decoction of Compatibility of Euphorbia fischeriana Steud and Jujubae |
| MA Liwei1 FAN Li2 NI Shiyu3 YU Hong3 ZHOU Li2 CHEN Zhe4 LIU Jicheng2 |
1.Graduae sohool, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Institute of Medical Science, Qiqihar Medical University, Heilongjiang Province, Qiqihar 161006, China;
3.Department of General Surgery, the Fifth Affiliated Hospital of Qiqihar Medical University, Heilongjiang Province, Daqing 163458, China;
4.School of Public Health, Qiqihar Medical University, Heilongjiang Province, Qiqihar 161006, China |
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Abstract Objective To study single drug toxicity of Euphorbia fischeriana Steud Powder (EFSP) and Decoction of Compatibility of Euphorbia fischeriana Steud and Jujubae (DEFSJ) and provide a reference for safe medication. Methods Modified Karber method was adopted to detect lethal dose 50 (LD50) and the 95% confidence interval of EFSP and DEFSJ. Blood biochemistry and histopathology were detected to evaluate the toxicity of EFSP and DEFSJ on liver and kidney of mice. Results The LD50 of EFSP was 2.12 g/kg, and the average 95% confidence interval was 1.61-2.78 g/kg. The LD50 of DEFSJ was 12.60 g/kg, and the average 95% confidence interval was 9.65-16.48 g/kg. Compared with the Jujubae Decoction group, as the dosage was increased, the mice weight was significantly decreased, however, organ coefficient was not obviously changed in EFSP and DEFSJ groups. The blood biochemical results showed that the levels of alanine transaminase and aspartate transaminase were elevated (P ＜ 0.05), and the levels of creatinine and blood urea nitrogen had an increased tendency. Pathological changes of kidney and liver were found by histopathological examination. Conclusion Both EFSP and DEFSJ have definite toxicity on kidney and liver.
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