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| Exploration on the medication rule of Professor Sun Shidao in the treatment of atopic dermatitis based on data mining |
| MA Xin ZHANG Huimin DING Peijun |
| Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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Abstract Objective To explore the medication experience of Professor Sun Shidao of Shanghai famous traditional Chinese medicine physician in the treatment of atopic dermatitis (AD). Methods The prescriptions treated with AD of Professor Sun Shidao in Special Outpatient Department of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2015 to January 2018 were collected. Based on the software of traditional Chinese medicine inheritance support system, unsupervised data mining methods such as association rule algorithm and entropy clustering of complex system were adopted. The prescription characteristics and medication rules of Professor Sun Shidao in the treatment of AD were analyzed. Results A total of 274 prescriptions were included in this study, involving 189 kinds of medicine. The drugs used more than 70 times included 18 kinds of medicine such as Cortex Moutan Radicis, Radix Sophorae Flavescentis, Rhizoma Anemarrhenae, Cortex Dictamni, Radix Scutellariae, Radix Scrophulariae, Rhizoma Smilacis Glabrae. The character of highest frequency used medicine mainly concentrated in cold, bitter, and liver channel of traditional Chinese medicine meridian. Seventeen drug combinations with a confidence level greater than 0.98 were obtained, eight core drug combinations were extracted, and four potential new therapeutic prescriptions were mined. Conclusion Professor Sun Shidao treats AD mainly by clearing heat, cooling blood and removing dampness, supplemented by invigorating spleen and benefiting qi, dispelling pathogenic wind and relieving itching.
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[1] 张学军.皮肤性病学[M].北京：人民卫生出版社，2017：109.
[2] 郑胜，孙丽蕴.基于中医古籍文献的特应性皮炎病名及鉴别[J].中华中医药杂志，2018，33（12）：148-150.
[3] 孙彩虹，顾恒.特应性皮炎的流行病学特征[J].中国医学文摘：皮肤科学，2016，33（2）：101-106，84.
[4] Weidinger S，Beck LA，Bieber T，et al. Atopic dermatitis [J]. Lancet，2016，387（10023）：1109-1122.
[5] Furue M，Chiba T，Tsuji G，et al. Atopic dermatitis：immune deviation，barrier dysfunction，IgE autoreactivity and new therapies [J]. Allergol Int，2017，66（3）：398-403.
[6] 林欢儿，李孜怡，彭静，等.中医药治疗特应性皮炎研究进展[J].辽宁中医药大学学报，2019，21（11）：29-32.
[7] 赵辨.中国临床皮肤病学[M].4版.南京：江苏科学技术出版社，2009：707.
[8] 陈红风.中医外科学[M].上海：上海科学技术出版社，2007：201.
[9] 杨洪军，唐仕欢，卢朋.中医传承辅助平台的开发与应用[M].福州：福建科学技术出版社，2013：11-14.
[10] 国家药典委员会.中国药典[M].北京：中国医药科技出版社，2015.
[11] 柳文红，杜华.从中医古籍探及“肺主皮毛”与特应性皮炎发病的关系[J].西北国防医学杂志，2017，38（11）：766-768.
[12] 黄楚君，朱梓波，薛素琴，等.特应性皮炎心脾相关病因病机理论的古文献探析[J].中国中西医结合皮肤性病学杂志，2018，17（5）：466-468.
[13] 邢华.朱仁康治疗异位性皮炎的经验[J].中华中医药学刊，2007，25（2）：229-230.
[14] 裴悦，莫秀梅，曾剑波，等.基于关联规则算法和复杂系统熵聚类的中医药治疗特应性皮炎的证治规律研究[J].中国医药导报，2019，16（3）：124-127.
[15] 王耀萍，孙世道.孙世道治疗湿疹经验[J].中医杂志，2010，51（S1）：103-104.
[16] 刘雷，郭丽娜，于春磊，等.白鲜皮化学成分及药理活性研究进展[J].中成药，2016，38（12）：2657-2665.
[17] 丛欢，李磊.白鲜皮提取物抗特应性皮炎实验研究[J].中国医学创新，2012，9（12）：18-19.
[18] 刘建萍，刘仲华，由宝昌，等.地肤子皂苷抗变态反应作用及其量效关系的研究[J].江苏农业科学，2007（5）：177-178.
[19] 吴春香，申万坤.地肤子醇提物止痒作用的实验研究[J].中医药临床杂志，2009，21（5）：449.
[20] 孟子琦，吴嘉瑞，杨艳平，等.基于网络药理学的“白鲜皮-地肤子”药对治疗特应性皮炎作用机制研究[J].中国医院用药评价与分析，2018，18（6）：725-728. |
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