当归补血汤合二妙散加减联合封闭负压引流技术治疗糖尿病足的效果

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Abstract Objective To explore the effect of Danggui Buxue Decoction combined with Ermiao Powder addition and subtraction combined with vacuum sealing drainage (VSD) technique on diabetic foot (DF). Methods From September 2017 to October 2019, 80 patients with DF from Qinhuangdao Military Hospital in Hebei Province were selected as the research subjects, the patients were divided into observation group and control group by random number table method, 40 cases in each group. Both groups were given basic treatment + debridement and dressing change. Based on this, the control group was given VSD technology, and the observation group was given Danggui Buxue Decoction and Ermiao Powder addition and subtraction combined with VSD technology. The clinical efficacy, symptom improvement (skin temperature, foot pain, bipedal ankle brachial index [ABI]), inflammatory indicators (procalcitonin [PCT], C-reactive protein [CRP]) and serum insulin-like growth factor-1 (IGF-1), pigment epithelium-derived factor (PEDF) levels were compared between the two groups before and after treatment. Results The total effective rate of the observation group was higher than that of the control group (P ＜ 0.05); after treatment, the skin temperature of the two groups was higher than before, and the pain score of the affected foot was lower than before (P ＜ 0.05), the skin temperature and ABI index of the observation group after treatment were higher than the control group, and the pain score of the affected foot was lower than the control group (P ＜ 0.05); after treatment, the levels of CRP, PCT and PEDF in both groups were lower than before treatment, and the levels of IGF-1 were higher than before treatment (P ＜ 0.05); after treatment, the levels of CRP, PCT and PEDF in the observation group were lower than those in the control group, and the levels of IGF-1 were higher than those in the control group (P ＜ 0.05). Conclusion Danggui Buxue Decoction and Ermiao Powder addition and subtraction combined with VSD technology for the first time in the treatment of DF, the effect is definite, can effectively improve clinical symptoms, shorten wound healing time, reduce inflammatory levels, and adjust serum levels of PEDF and IGF-1.

Key words： Danggui Buxue Decoction Ermiao Powder Vacuum sealing drainage technology Diabetic foot

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	ZHANG Yang1 GENG Haitao2 LIU Yuanwei1 ZHANG dan3 WANG Yan1 SONG Rui4 ZUO Weiwei4

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ZHANG Yang1 GENG Haitao2 LIU Yuanwei1 ZHANG dan3 WANG Yan1 SONG Rui4 ZUO Weiwei4. Effect of Danggui Buxue Decoction and Ermiao Powder addition and subtraction combined with vacuum sealing drainage technique on diabetic foot[J]. 中国医药导报, 2020, 17(36): 82-86.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I36/82

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