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| Research progress on the protective mechanism of Propofol on ischemic brain injury |
| HUANG Rui LIU Zhigang▲ |
| Department of Anesthesiology, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract Ischemic brain injury (IBI) is one of the main causes of adult disability. IBI causes neuro-inflammation, oxidative stress and cell apoptosis to damage neurons, and current treatments for IBI are limited. As a commonly used intravenous anesthetic in clinical practice, in addition to its sedative and hypnotic effects, Propofol also has the effects of reducing cerebral blood flow and lowering brain metabolism. It can be passed through phosphoinositide 3-kinase (PI3K)/serine-threonine protein kinase (Akt) pathway and Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB pathway play an anti-inflammatory effect, reduce the production of oxygen free radicals and resist cell apoptosis, and play a protective role in ischemic brain tissue and neurons. The protective effect of Propofol may become a new target for clinical treatment of IBI.
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