乳腺癌化疗性脱发的中医治疗现状与展望

Abstract
Figure/Table
References (32)
Related Citation (15)

Download: PDF (513 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Chemotherapy-induced alopecia（CIA）, as one of the frightening side effects for most breast cancer patients, has a negative effect on patients’ psychology state and compliance of treatment. Traditional Chinese medicine has unique advantages in the prevention and treatment of CIA with the theory that hair is the surplus of the blood, kidney stores the essence and has its manifestations in hair. The etiology and pathogenesis of CIA in traditional Chinese medicine are that the medicine pathogen of chemotherapeutics can cause the deficiency of both qi and blood as well as the deficiency of liver-kidney yin, thus lead to the undernutrition of hair or the stagnation of liver qi can then cause the combination of qi stagnation and blood stasis syndrome, which makes the stagnated blood lock collaterals, and the hair may also lose nourishment. So the treatment of CIA should be applied by invigorating qi and nourishing blood, tonifying liver and kidney, or promoting blood circulation to remove meridian obstruction respectively based on the traditional Chinese medicine syndrome differentiation and treatment system. Basic medical research showed that the mechanism of Chinese herbs in treating CIA is related to the inhibition of corticotropin-releasing factor receptor and prostaglandin D2 synthetase.

Key words： Breast cancer Chemotherapy-induced alopecia Etiology and pathogenesis Traditional Chinese medicine therapy

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Zhaodongfang1 ZHOU Jialin1 LIU Sida1 WAN Donggui2

Cite this article:

WANG Zhaodongfang1 ZHOU Jialin1 LIU Sida1 WAN Donggui2. Current situation and prospect on the treatment of chemotherapy-induced alopecia in breast cancer patients based on traditional Chinese medicine[J]. 中国医药导报, 2020, 17(36): 49-52.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I36/49

[1] Ghoncheh M，Pournamdar Z，Salehiniya H. Incidence and Mortality and Epidemiology of Breast Cancer in the World [J]. Asian Pac J Cancer Prev，2016，17（S3）：43-46.
[2] Bray F，Ferlay J，Soerjomataram I，et al. Global cancer statistics 2018：GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin，2018，68（6）：394-424.
[3] 张阳，田丽，陈长英.化疗致脱发对癌症病人治疗依从性的影响及护理进展[J].护理研究，2017，31（29）：3643-3646.
[4] Nalluri R，Harries M. Alopecia in general medicine [J]. Clin Med（Lond），2016，16（1）：74-78.
[5] Trusson D，Pilnick A. The Role of Hair Loss in Cancer Identity：Perceptions of Chemotherapy-Induced Alopecia Among Women Treated for Early-Stage Breast Cancer or Ductal Carcinoma in Situ [J]. Cancer Nurs，2017，40（2）：E9-E16.
[6] 翁慧雯，李映红.化疗脱发对女性患者身体意象及生命质量的影响[J].现代医院，2017，17（1）：151-153，156.
[7] Dua P，Heiland MF，Kracen AC，et al. Cancer-related hair loss：a selective review of the alopecia research literature [J]. Psychooncology，2017，26（4）：438-443.
[8] Watanabe T，Yagata H，Saito M，et al. A multicenter survey of temporal changes in chemotherapy-induced hair loss in breast cancer patients [J]. PLoS One，2019，14（1）：e208118.
[9] Brower V. Scalp cooling and hair loss during breast cancer chemotherapy [J]. Lancet Oncol，2017，18（4）：e199.
[10] Cigler T，Isseroff D，Fiederlein B，et al. Efficacy of Scalp Cooling in Preventing Chemotherapy-Induced Alopecia in Breast Cancer Patients Receiving Adjuvant Docetaxel and Cyclophosphamide Chemotherapy [J]. Clin Breast Cancer，2015，15（5）：332-334.
[11] Daanen HA，Peerbooms M，van den Hurk CJ，et al. Core temperature affects scalp skin temperature during scalp cooling [J]. Int J Dermatol，2015，54（8）：916-921.
[12] 翟文娟，梁栋.从脾胃失调论治乳腺癌化疗不良反应[J].中国民族民间医药，2017，26（17）：75-77.
[13] 田浩君，马葳.中医防治肿瘤放化疗后脱发思考[J].内蒙古中医药，2017，36（5）：30-31.
[14] 文琪，杜七玉，田俊，等.运用“鸡血路”之活血通络法治疗脱发的探讨[J].世界最新医学信息文摘，2017，17（14）：143-145.
[15] 贾英杰，于建春，杨佩颖，等.扶正解毒祛瘀法防治化疗后骨髓抑制的探讨[J].中医杂志，2014，55（3）：198-201.
[16] 李娜，孙一予，李小江.贾英杰教授治疗化疗后脱发经验介绍[J].现代中西医结合杂志，2010，19（21）：2690.
[17] 王丰莲.八珍汤改善乳腺癌化疗患者毛发超微结构的研究[J].实用药物与临床，2018，21（7）：794-797.
[18] 刘清源，夏婷婷，骆丽娜，等.乳腺癌化疗后中医证型与化疗副反应的相关性研究[J].浙江中医杂志，2016，51（9）：631-632.
[19] 唐雪纯，杭晓屹，黄祥实，等.当代中医名家辨治脱发用药规律研究[J].中医学报，2019，34（8）：1651-1659.
[20] 李香凤.首乌饮防治乳腺癌AC-P方案化疗致脱发的临床观察[D].福州：福建中医学院，2008.
[21] Leem J，Jung W，Kim Y，et al. Exploring the combination and modular characteristics of herbs for alopecia treatment in traditional Chinese medicine：an association rule mining and network analysis study [J]. BMC Complement Altern Med，2018，18（1）：204.
[22] Patel S，Sharma V，Chauhan NS，et al. A study on the extracts of Cuscuta reflexa Roxb. in treatment of cyclophosphamide induced alopecia [J]. Daru，2014，22（1）：7.
[23] 陈远前，叶人，袁拯忠.活血化瘀法在乳腺癌术后放化疗后的临床应用[J].浙江中医药大学学报，2019，43（6）：591-594.
[24] 段桦，周天，胡凯文.益气活血法在恶性肿瘤治疗中的应用及其作用机制研究概况[J].中医杂志，2020，61（2）：169-173.
[25] 张俊生，车洪勇.养气养血活血化瘀中药配伍联合化疗治疗乳腺癌临床观察[J].四川中医，2016，34（2）：123-125.
[26] Yu F，Li Y，Zou J，et al. The Chinese herb Xiaoaiping protects against breast cancer chemotherapy-induced alopecia and other side effects：a randomized controlled trial [J]. J Int Med Res，2019，47（6）：2607-2614.
[27] 吴涛，马金丽，陆明.陆明运用中医扶正祛邪法治疗乳腺癌经验[J].北京中医药，2017，36（3）：251-253.
[28] 贺新爱，郜娜娜，马馨，等.中药治疗对乳腺癌术后放化疗患者生活质量及毒副反应的影响[J].肿瘤药学，2016， 6（5）：349-355.
[29] 艾望，张曼玲，沈鑫，等.抑癌扶正法在乳腺癌综合治疗中的应用[J].湖北中医药大学学报，2019，21（4）：126-129.
[30] 于洪艺，吕爱平.论五脏六腑与毛发的相关性[J].辽宁中医药大学学报，2019，21（2）：162-165.
[31] Huang HJ，Chen CY. A possible solution for hair loss by inhibiting corticotropin-releasing factor（CRF）receptor from traditional Chinese medicine [J]. J Biomol Struct Dyn，2014，32（10）：1613-1623.
[32] Fong P，Tong HH，Ng KH，et al. In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss [J]. J Ethnopharmacol，2015，175（6）：470-480.