白三烯B4/白三烯B4受体通路在脑缺血损伤发生机制中的研究进展

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Abstract Leukotriene B4 (LTB4) is one of the downstream products of arachidonic acid metabolized by 5-lipoxygenase, and it is a potent pro-inflammatory lipid mediator. By sorting out the existing literature, it is found that after cerebral ischemia, neurons, microglia and astrocytes release LTB4, which promotes neutrophil infiltration and release inflammatory factors, leading to secondary brain injury after cerebral ischemia. Further study on the role and mechanism of targeting LTB4-BLTR axis in inflammatory response after cerebral ischemia injury can find new effective therapeutic drugs for cerebral ischemia injury.

Key words： Cerebral ischemia Leukotriene B4 Leukotriene B4 receptors Neutrophil

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	LI Huimin XIANG Jingyun WU Jie WANG Yan ZHOU Shuang SHI Yongheng WANG Chuan WANG Bin

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LI Huimin XIANG Jingyun WU Jie WANG Yan ZHOU Shuang SHI Yongheng WANG Chuan WANG Bin. Research progress of leukotriene B4/leukotriene B4 receptor pathway in the mechanism of cerebral ischemic injury[J]. 中国医药导报, 2020, 17(31): 50-53.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I31/50

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