鸡蛋过敏患者外周血清中半乳糖凝集素-3的表达及与鸡蛋特异性IgE的相关性

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Abstract Objective To detect the expression of galectin-3(Gal3) in serum of patients with egg allergy and the correlation with egg-specific IgE. Methods Screening 68 patients with egg allergy according to the history of allergy, prick test, egg-specific IgE and food exclusion from April 2016 to April 2017 in Department of Allergy of Tongji hospital Affiliated to Tongji Medical College of Huazhong University of Science & Technology. The patients with egg allergymanifested withanaphylactic shock, eczema, chronic urticaria, mild dermatitis, allergic asthma, cough variant asthma and allergic rhinitis were selected as egg allergy group. Twenty patients with no history of allergies, skin prick test and egg serum specific IgE were negative were selected as healthy controlsin the same period. The correlation between Gal3 expression and egg-specific IgE in patients with different symptoms was analyzed. Results The average concentration of Gal3 in serum of control group was (4.23±0.53) ng/mL, the average concentration of Gal3 in serum of egg allergy group was(9.95±6.31)ng/mL. The difference was statistically significant (P = 0.0032). The expression of Gal3 in each group: the concentration of Gal3 in anaphylactic shock group was (17.11±2.54) ng/mL and allergic asthma was (10.95±1.97) ng/mL significant higher than those of control group, the difference was statistically significant (P= 0.0007, 0.0001); the group of chronic urticaria was (6.71±2.13) ng/mL and allergic rhinitis was(7.24±1.75) ng/mL, compared with the control group, the differences were statistically significant (P = 0.038, 0.022); the eczema group (5.04±0.15) ng/mL, mild dermatitis group was(4.24±1.33) ng/mL and cough variant asthma group was (3.24±2.75) ng/mL, the differences were not statistically significant(P = 0.156, 0.354, 0.282 respectively). The expression of Gal3 was positively correlated with egg-specific IgE in serum (r = 0.5932). There was a positive correlation among allergic asthma, allergic rhinitis and cough variant asthma in patients with egg-specific IgE (r = 0.7792, 0.8658, 0.8091, all P < 0.01), but there was no significant difference between Gal3 expression and egg-specific IgE in the other symptoms (P > 0.05). Conclusion The expression of Gal3 in serum of patients with allergic asthma, allergic rhinitis and chronic urticaria was significantly increased, which can prompt allergy patients provoked by egg.

Key words： Galectin-3 Egg allergy Foodallergy Specific IgE

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	ZHANG Shuchen YANG Lin HU Lintao YANG Yongshi ZHU Rongfei

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ZHANG Shuchen YANG Lin HU Lintao YANG Yongshi ZHU Rongfei. The expression of galectin-3 in serum of patients with egg allergy and its correlation with egg-specific IgE[J]. 中国医药导报, 2018, 15(1): 64-67.

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