Objective To explore the syndrome differentiation thinking in treatment of metrorrhagia and metrostaxis in Zhulinsi Nvke Zhengzhi, and to explore the regularity of medication in metrorrhagia and metrostaxis. Methods Took Zhulinsi Nvke Zhengzhi as the retrieval source. The syndrome treatment literatures related to the collapse of the book were collected and sorted out. The clinical thoughts of Zhu Lin′s buddhist doctor in the treatment of the collapse were analyzed, the names of the formulas included were extracted, the recipe database was established, and frequency analysis of the data was conducted. SPSS Statistic 22.0 and SPSS Modeler 14.1 were used to cluster analysis and correlation analysis for high frequency drugs. Results Through screening, 24 prescriptions for metrorrhagia and metrostaxis were obtained. Hematonic drug, qi-tonifying drug, superficies-relieving drug, antipyretic drug, bleeding-arresting preparation drug were high frequency medication. Liquorice root, Chinese angelica, prepared rehmannia root, Sichuan lovage rhizome, debark peony root, baical skullcap root, unprocessed rehmannia root, ect. were specific high-frequency drugs. Chinese angelica was the core drug. Five core drug groups were observed by cluster analysis. According to the correlation analysis, the traditional Chinese medicine with potential association rules were Chinese angelica and debark peony root, Chinese angelica and Sichuan lovage rhizome. Conclusion Based on the analysis of the literatures and prescriptions in the treatment of metrorrhagia and metrostaxis in Zhulinsi Nvke Zhengzhi, it is concluded that the treatment of metrorrhagia and metrostaxis by Zhu Lin′s buddhist doctor attaches great importance to benefiting qi for promoting production of blood, coordinating spleen and stomach, and the data mining results are consistent with the traditional theory, which is reasonable and effective.