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| Clinical and pathological features of 116 patients with proliferative and sclerosing IgA nephropathy |
| CHANG Meiying ZHANG Yu |
| Department of Nephropathy, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China |
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Abstract Objective To investigate the clinical and pathological features of patients with proliferative and sclerosing IgA nephropathy. Methods Retrospective analysis was performed on 116 patients with proliferative and sclerosing IgA nephropathy confirmed by renal biopsy in Department of Nephropathy, Xiyuan Hospital, China Academy of Chinese Medical Sciences from January 2015 to March 2019. According to chronic kidney diseases (CKD) stage, they were divided into CKD stage 1-5. The 24 h urinary protein quantification and comorbidities of each group were compared (including the presence or absence of hypertension, hyperuricemia, etc.). They were divided into group with ischemic kidney injury and group without ischemic kidney injury according to the presence or absence of ischemic kidney injury, and they were divided into group with IgM deposition and group without IgM deposition according to the presence or absence of IgM deposition group. The 24 h urinary protein quantification, serum creatinine level and estimated glomerular filtration rate (eGFR) of each group were compared. Results There were statistically significant differences among the five groups in age, 24 h urine protein quantification, and proportion of hyperuricemia, pharyngitis and tonsillitis (all P < 0.05). The serum creatinine and proportion of hypertension in group with ischemic kidney injury were higher than those of the group without ischemic kidney injury, and eGFR was lower than that of the group without ischemic kidney injury, with statistically significant differences (all P < 0.05). The age and eGFR level of group with IgM deposition were lower than those of group without IgM deposition, the serum creatinine level was higher than that of group without IgM deposition, and the differences were statistically significant (all P < 0.05). Conclusion The clinical and pathological lesions in patients with proliferation and sclerosing IgA nephropathy are severe, and 24 h urine protein quantitative, blood creatinine, ischemic kidney injury and IgM deposition may be risk factors for renal progression and poor renal prognosis.
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