一氧化二氮暴露对神经系统的影响进展

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Abstract Long-term nitrous oxide (N2O) exposure can cause neurological damage mainly manifested as spinal cord lesions. Patients generally have a gradual onset and progressive condition. The clinical manifestations are limb paresthesia and ataxia, some patients have symptoms of peripheral nerve injuries and extrapyramidal tracts injuries, it may cause cognitive dysfunction and mental abnormalities. Since the increase in clinical case reports of N2O abuse, it is of great significance to research the effects of N2O exposure on the nervous system. Therefore, after a systematic review of related literature and case reports, this paper summarizes the injury mechanism, clinical manifestations, exposure methods, diagnosis, treatment and prognosis of N2O exposure. We hope to strengthen the awareness of the disease, and to provide some ideas for diagnosis and treatment.

Key words： Nitrous oxide Vitamin B12 Subacute combined degeneration Peripheral neuropathy

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	LI Yi′na1 LI Mingyang1 XIAO Zheman2 LIANG Jingjing2

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LI Yi′na1 LI Mingyang1 XIAO Zheman2 LIANG Jingjing2. Progress in the effects of nitrous oxide exposure on the nervous system[J]. 中国医药导报, 2020, 17(28): 36-39.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I28/36

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