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| Meta-analysis of blood activating therapy combined with acupuncture in the treatment of vascular cognitive impairment |
| TAN Jingfei1 XU Xiu2 ZHANG Zhongping2 SHI Jian2 LIAN Mengjie1 |
1.Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2.Department of Rehabilitation, Clifford Hospital, Guangdong Province, Guangzhou 511495, China |
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Abstract Objective To systematically evaluate the effect of blood activating therapy combined with acupuncture in the treatment of vassular cognitive impairment (VCI). Methods Based on the key words of “promoting blood circulation”, “removing blood stasis”, “dredging collaterals”, “acupuncture”, “vascular cognitive impairment”, “vascular dementia” and “post stroke dementia”, this study searched CBM, CNKI, Wanfang Data, VIP, PubMed and Web of Science from the establishment of the database to November 2019. Randomized controlled trials (RCTs) published in these database were studied. Meta-analysis was performed by RevMan 5.3 software. Results Thirteen trials involving 1150 patients were included. The meta-analysis results showed that the method of promoting blood circulation combined with acupuncture could improve the curative effects of VCI patients (OR = 3.65, 95%CI [2.49, 5.35], P ＜ 0.000 01), mini mental status examination scores (MD = 3.49, 95%CI [2.18, 4.80], P ＜ 0.000 01), Montreal cognitive assessment scores (MD = 1.73, 95%CI [0.78, 2.69], P = 0.0004) and reduce the scores of National Institute of Health stroke scale (MD = -3.36, 95%CI [-4.25, -2.47], P ＜ 0.000 01) as well as whole blood viscosity (MD = -0.78, 95%CI [-1.04, -0.53], P ＜ 0.000 01). Conclusion On basis of the conventional Western medicine treatment, combination of promoting blood circulation and acupuncture for VCI is significantly better than using Western medicine alone in improving cognitive dysfunction, restoring defective nerve function and reducing whole blood viscosity.
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