中药穴位敷贴治疗原发性痛经效果的meta分析

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Abstract Objective To evaluate the curative effect of acupoint application of traditional Chinese medicine (TCM) on primary dysmenorrhea. Methods After two researchers screened the literature independently, extracted the data and evaluated the risk of bias, the meta-analysis was performed by Stata 14.0 software. Chinese databases were searched including CNKI, Wanfang Data, CBM, VIP, and English databases included PubMed, Embase, the Cochrane Library and Web of Science. The retrieval period was from database construction to July 2019. Results There were 16 studies included, with 1366 patients. Meta-analysis showed that acupoint application of TCM was superior to nonsteroidal anti-inflammatory drugs in terms of clinical total response rate (RR = 1.34, 95%CI [1.18, 1.53], P ＜ 0.0001), reduction of dysmenorrhea symptom score (WMD = 3.03, 95%CI [2.56, 3.49], P ＜ 0.0001), reduction of visual analogue score (VAS) (WMD = 1.11, 95%CI [0.79, 1.43], P ＜ 0.0001) in the treatment of primary dysmenorrhea. In addition, acupoint application of TCM was better than placebo in reducing VAS score (WMD = 2.26, 95%CI [1.90, 2.62], P ＜ 0.0001), reducing duration of dysmenorrhea (WMD = 10.93, 95%CI [7.99, 13.87], P ＜ 0.0001) and severity of onset level (WMD = 6.52, 95%CI [5.05, 7.99], P ＜ 0.0001). Compared with traditional Chinese patent analgesics, there was a certain advantage in reducing dysmenorrhea symptom score (WMD = 3.56, 95%CI [2.33, 4.78], P ＜ 0.0001), but there was no significant difference in clinical efficacy (RR = 1.17, 95%CI [0.99, 1.39], P = 0.06). Conclusion Acupoint application of TCM has certain curative effect on primary dysmenorrhea, but the results need to be further verified by more high-quality RCTs.

Key words： Acupoint application Primary dysmenorrhea Randomized controlled trials Meta-analysis

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	SONG Changmei GAO Chunyang FU Yanlai ZHANG Jin

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SONG Changmei GAO Chunyang FU Yanlai ZHANG Jin. Meta-analysis on the efficacy of acupoint application of traditional Chinese medicine in the treatment of primary dysmenorrhea[J]. 中国医药导报, 2020, 17(26): 129-133.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I26/129

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