慢性心力衰竭患者同型半胱氨酸、肌钙蛋白T、高敏C反应蛋白与心功能的相关性研究

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Abstract Objective To investigate the relationship between homocysteine (Hcy), troponin T (TNT), high sensitive C-reactive protein (hs-CRP) and cardiac function in patients with chronic heart failure. Methods One hundred and fifteen patients with chronic heart failure admitted to the Department of Cardiology, Rocket Army General Hospital from January 2016 to January 2019 were selected as heart failure group. According to the New York Heart Association (NYHA) cardiac function classification standard, the heart failure group was divided into NYHA class Ⅱ group (26 cases), NYHA class Ⅲ group (35 cases) and NYHA class Ⅳ group (54 cases). Ninety-five healthy elderly people who had physical examination at the same time were selected as control group. The levels of Hcy, TNT, hs-CRP, NT-proBNP and left ventricular ejection fraction (LVEF) in each group were compared, and the correlation between Hcy, TNT, hs-CRP and NT-proBNP, LVEF were analyzed. Results The levels of TNT, hs-CRP, Hcy and NT proBNP in heart failure group were higher than those in control group, and LVEF was lower than that in control group (P < 0.01). The cardiac function was graded from grade Ⅱ to grade Ⅳ, the levels of serum TNT, hs-CRP, Hcy and NT-proBNP increased gradually, LVEF decreased gradually, the differences were statistically significant (P < 0.01). The levels of serum TNT, hs-CRP and Hcy were positively correlated with NT-proBNP (r = 0.75, 0.61, 0.69), and negatively correlated with LVEF (r = -0.71, -0.59, -0.64), and the differences were statistically significant (P < 0.05). Conclusion The levels of Hcy, TNT and hs-CRP in patients with heart failure are significantly increased, and the levels of Hcy, TNT and hs-CRP are positively correlated with NT-proBNP, and negatively correlated with LVEF. Therefore, they can be used as important indicators to evaluate the severity of heart failure.

Key words： Heart failure Homocysteine Troponin T High sensitive C-reactive protein

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	LU Xin1 DING Liping1 GAO Guojie1 ZHANG Zheng1 WANG Chengzhu1 ZHANG Lijuan1 JIN Zhitao1▲ ZHAO Guifeng2▲

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LU Xin1 DING Liping1 GAO Guojie1 ZHANG Zheng1 WANG Chengzhu1 ZHANG Lijuan1 JIN Zhitao1▲ ZHAO Guifeng2▲. Relationship study between homocysteine, troponin T, high sensitivity C-reactive protein and cardiac function in patients with chronic heart failure[J]. 中国医药导报, 2020, 17(26): 45-48.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I26/45

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