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| Clinical study of Duyiwei Capsules combined with Cetylpyridinium Chloride Gargle in the treatment of gingivitis |
| CAI Xin1 CUI Junxia2 LYU Qiufeng3 |
1.Department of Atomatology, Liaoning Health Industry Group Fuxin Mine General Hospital, Liaoning Province, Fuxin 123000, China;
2.Department of Comprehensive Emergency, Stomatology Hospital of Shenyang, Liaoning Province Shenyang 110000, China;
3.Department of Comprehensive Stomatology, Chengxi District of Hangzhou Dental Hospital, Zhejiang Province, Hangzhou 310000, China |
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Abstract Objective To explore the clinical effect of Duyiwei Capsules combined with Cetylpyridinium Chloride Gargle in the treatment of gingivitis. Methods A total of 80 patients with gingivitis admitted to Liaoning Health Industry Group Fuxin Mine General Hospital from October 2018 to October 2019 were selected and they were divided into control group (treatment with Cetylpyridinium Chloride Gargle) and study group (treatment with Duyiwei Capsules+Cetylpyridinium Chloride Gargle) according to the random number table method, with 40 cases in each group. Both groups were continuously treated for 15 days. The clinical efficacy, gingival recovery, changes of inflammatory factors and adverse reactions were compared between the two groups. Results After treatment, the total clinical effective rate of the study group was higher than that of the control group (P ＜ 0.05). After treatment, gingival index, sulcus bleeding index and plaque index in the two groups were lower than those before treatment, and the study group were lower than those of the control group (P ＜ 0.05). After treatment, the levels of interleukin-1β, tumor necrosis factor-α, prostaglandin E2, soluble adhesion molecule 1 and C-reactive protein were lower in the two groups than before treatment, and the study group were lower than those of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The treatment of gingivitis patients with Duyiwei Capsules combined with Cetylpyridinium Chloride Gargle can achieve a better clinical effect. The mechanism may be improve the gingival crevicular hemorrhage and the number of dental plaque and other clinical manifestations by reducing the inflammatory response of patients, so as to play a therapeutic role, which can be widely used in clinical.
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