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| Effect of Insulin Glargine combined with Repaglinide on hyperglycemia in patients with first-onset type 2 diabetes and its effect on islet β cell function |
| ZUO Lijuan1 LI Mingxia1 DENG Wenjuan1 GU Jun1 MA Hongwei2 REN Weidong1 |
1.Department of Endocrinology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of Nuclear Medicine, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China |
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Abstract Objective To investigate the effect of Insulin Glargine combined with Repaglinide on hyperglycemia in patients with type 2 diabetes (T2DM). Methods Seventy-two patients with first-onset T2DM who were admitted to the First Affiliated Hospital of Hebei North University from February 2017 to December 2018 were selected and divided into combined group (Insulin Glargine + Repaglinide) and control group (premixed Insulin) according to random number table method, with 36 cases in each group. After 3 months of treatment, the blood glucose (fasting blood glucose [FBG], 2-hour postprandial blood glucose [2hPBG], glycated hemoglobin [HbA1c]), blood lipid (total cholesterol [TC], triglycerides [TG], and low density lipoprotein-cholesterol [LDL-C], high density lipoprotein-cholesterol [HDL-C]), inflammatory factors (interleukin-6 [IL-6], monocyte chemoattractant protein-1 [MCP-1], serum amyloid A [SAA]), islet β cell function indicators (fasting insulin [FINS], HOMA islet β cell function index [HOMA-β], HOMA insulin resistance index [HOMA-IR]) were compared between the two groups, and the occurrence of hypoglycemia was evaluated. Results After treatment, TC, TG, LDL-C levels decreased and HDL-C levels increased in the two groups, TC, TG, LDL-C levels in the combined group were lower than those in the control group, and HDL-C level was higher than the control group (all P ＜ 0.05). After treatment, serum IL-6, MCP-1, SAA levels decreased in the two groups, which in the combined group were lower than those in the control group (all P ＜ 0.05). After treatment, FBG, 2hPBG, and HbA1c levels were decreased in the two groups, which in the combined group were lower than those in the control group (all P ＜ 0.05). After treatment, FINS and HOMA-β increased with HOMA-IR decreased in the two groups, the combined group improved better than the control group (all P ＜ 0.05), and there was no significant difference in HOMA-IR between the two groups after treatment (P ＞ 0.05). The incidence of hypoglycemia in the combined group was lower than that in the control group (P ＜ 0.05), and there was no significant difference between the two groups in the rate of blood glucose reaching the standard (P ＞ 0.05). Conclusion For patients with first-onset T2DM with hyperglycemia, Insulin Glargine combined with Repaglinide has obvious effects on blood glucose and lipids, and can effectively protect islet β-cell function, inhibit inflammation, and reduce the incidence of hypoglycemia.
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