大连石城岛原驻老年居民PON1rs662基因多态性与高血压及其相关因素的关系研究

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Abstract Objective To investigate the prevalence and related factors of hypertension in the elderly in Shicheng Island of Dalian, and the relationship between serum P-oxophosphase 1(rs662) gene(PON1rs662) and hypertension. Methods The epidemiological survey on hypertension and related factors was conducted among 654 residents aged more than 65 from June to August 2016. The adjusted WHO-MONICA research questionnaire was used for questionnaire survey, biochemical and echocardiographic examinations were carried out. DNA was extracted by centrifugation column, and gene typing of PON1rs662 was carried out by TaqMan PCR. All the studies were determined whether the genotype distribution of PONIrs662 accord with Hardy-Weinberg Law, and the relationship between PON1rs662 gene and hypertension was investigated. Results The prevalence of hypertension was 73.1%, 77.5% in women and 68.3% in men. There were statistically significant differences in heart rate, body mass index (BMI), waist circumference, uric acid (UA), triglyceride (TG) and left atrial anteropostery (LA) between hypertensive and non-hypertensive subjects (P ＜ 0.05). The genotype distribution of PON1rs662 was in line with Hardy-Weinberg Law (P ＞ 0.05). Both the allele model and the additive moded showed no correlation between the PON1rs662 SNP and hypertension (P > 0.05). Conclusion The prevalence rate of hypertension in the old residents of Shicheng Island was 73.1%. Heart rate, BMI, waist circumference, UA and TG were associated with the prevalence of hypertension on the island. PON1rs662 gene may not be correlated with the prevalence of hypertension in these study objects.

Key words： Serum p-oxophosphase 1 (rs662) gene Hypertension Island Old-man Single nucleotide polymorphism

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	HE Lan1 TANG Xiaohui2 HU Jiahui2 CHENG Dong2 WANG Xingyu3 YU Qin2

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HE Lan1 TANG Xiaohui2 HU Jiahui2 CHENG Dong2 WANG Xingyu3 YU Qin2. Study on the relationship between PON1rs662 gene polymorphism and hypertension and its related factors in Shicheng Island of Dalian[J]. 中国医药导报, 2020, 17(24): 51-54.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I24/51

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