|
|
Effects of early, middle and late three stages of Chinese medicine decoction gauze sequential dressing change on wound healing after low simple anal fistula operation |
LIU Yang LI Xianyuan GAO Ling |
Department of Anorectal, Lu′an Hospital of Traditional Chinese Medicine, Anhui Province, Lu′an 237006, China |
|
|
Abstract Objective To investigate the effect of early, middle and late three stages of Chinese medicine decoction gauze sequential dressing change on wound healing after low simple anal fistula operation. Methods One hundred and eighteen patients with low simple anal fistula from January 2018 to January 2020 in Lu′an Hospital of Traditional Chinese Medicine of Anhui Province were selected by using stratified sampling method. They were divided into two groups by using random number table method, with 59 cases in each group. Control group was treated with Vaseline Oil, and study group was treated with gauze of traditional Chinese medicine decoction at early, middle and late three stages. Visual analogue scale (VAS), wound bleeding score, wound exudate score and wound area were compared between two groups before and after treatment, and the wound healing rate, wound healing time and postoperative wound related complications were counted. Results The overall analysis showed that there were significant differences in VAS, wound bleeding and exudate score between groups, time point comparison and interaction (P < 0.05). It was suggested that the postoperative wound bleeding and exudation of two groups were significantly improved, and the pain became lighter and lighter. Further pairwise comparison, intra group comparison: VAS score of the patients in two groups decreased gradually compared with that before treatment in the first week, the second week and the third week after operation (P < 0.05). Comparison between groups: VAS of study group at the first week, the second week and the third week after operation was significantly lower than that of control group (P < 0.05). Intra group comparison: at the first week, the second week and the third week after operation, the wound bleeding, exudate integral and wound area of two groups were gradually reduced compared with those before treatment (P < 0.05). Comparison between groups: the wound bleeding, exudation integral and wound area of study group at the first week, the second week and the third week after operation were lower or smaller than those of control group (P < 0.05). The wound healing rate of study group was higher than that of control group at the third week after operation, and the wound healing time was shorter than that of control group (P < 0.05). The incidence of wound related complications in study group was lower than that in control group (P < 0.05). Conclusion The sequential dressing change of traditional Chinese medicine decoction gauze in the early, middle and late three stages after the operation of low simple anal fistula can reduce the degree of pain, reduce the blood and liquid oozing from the wound, improve the wound healing effect and reduce the risk of wound related complications.
|
|
|
|
|
[1] Yi HS,Qiu JM,Yang GG,et al. Differential gene expression in patients with anal fistula reveals high levels of prolactin receptor [J]. Vojnosanit Pregl,2017,71(11):1040-1044.
[2] 李文,侯宗华,于庆生.手术联合双花黄芪汤治疗肛瘘临床研究[J].中国中医基础医学杂志,2018,24(4):515-517.
[3] Vogel JD,Johnson EK,Morris AM,et al. Clinical practice guideline for the management of anorectal abscess,fistula-in-ano,and rectovaginal fistula [J]. Dis Colon Rectum,2016,59(12):1117-1133.
[4] 国家药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:24-26.
[5] 艾登斌,谢平,许慧.简明疼痛学[M].北京:人民卫生出版社,2016:86.
[6] 盛尹菁.敛痔散外敷促进低位单纯性肛瘘术后创面愈合疗效观察[J].现代中西医结合杂志,2017,26(10):1098-1100.
[7] Birkett RT,Hall JF. Optimal management of the transsphincteric anal fistula [M]. Difficult Decisions Colorectal Surgery,2017:63-65.
[8] Broeck TVD,Gheldere CD. A gastric feeding tube as a non-traumatic fistula probe during anal fistula repair [J]. Tech Coloproctol,2018,22(1):125-127.
[9] Eberspacher C,Mascagni D,Fralleone L,et al. Pilonidal disease mimicking anterior anal fistula and associated with posterior anal fistula:a two-step surgery. Case report [J]. G Chir,2017,38(6):313-317.
[10] Manuel FM,Natalia EC,Ángel RD,et al. Analysis and description of disease-specific quality of life in patients with anal fistula [J]. Am Surg,2018,96(4):213.
[11] 沈江涌,马强,杨智斌,等.紫草油剂对全层皮肤缺损大鼠创面愈合的影响及相关机制[J].中华烧伤杂志,2017, 33(9):562-567.
[12] 邱全玉,邱昆成,孙振刚,等.LC-MS/MS同时测定配伍知母对黄柏中5种成分含量的影响[J].中药材,2017, 40(12):2884-2887.
[13] 胡政宇,周鸿立.白芷多糖提取分离及其生物活性的研究进展[J].中国调味品,2017,42(12):174-177.
[14] 陈阳.紫草素及其衍生物抗肿瘤作用研究进展[J].中草药,2019,50(14):3503-3509.
[15] 朱赟,鲁林源,孙琼,等.复方紫草油和高锰酸钾应用于肛瘘术后的作用对比研究[J].世界中医药,2018,13(6):1368-1371,1375.
[16] 高茹梦,张立雯,缪晓冬,等.乳香-没药药对中萜类成分的提取工艺优化研究[J].南京中医药大学学报,2019, 35(3):332-337.
[17] 汤丹,肖伟,钱正明,等.活细胞固相色谱法联合高分辨质谱快速筛选龙血竭中镇痛活性成分[J].中草药,2019, 50(11):2539-2544.
[18] 王雪,杨婧,袁红,等.丹参素冰片酯对同型半胱氨酸诱导大鼠骨髓间充质干细胞损伤的保护作用及机制[J].中华心血管病杂志,2017,45(2):130-136.
[19] 何大香,朱虹霖.愈创汤治疗肛瘘术后创面瘢痕组织的疗效及其对胶原Ⅰ和胶原Ⅲ的影响[J].世界中医药,2018, 13(3):632-634,639.
[20] 罗宏标,陈鸣旺,廖莎.中药汤剂序贯换药促进低位单纯性肛瘘术后创面愈合30例疗效观察[J].湖南中医杂志,2017,33(1):55-57. |
|
|
|