补阳还五汤联合强化降脂抗凝药治疗气虚血瘀证缺血性中风的效果

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Abstract Objective To explore the effect of Buyang Huanwu Decoction combined with enhanced lipid-lowering and anticoagulation in the treatment of ischemic stroke with syndrome of qi deficiency and blood stasis. Methods Two hundred patients of ischemic stroke with syndrome of qi deficiency and blood stasis admitted to Anhui Huaibei People′s Hospital from December 2015 to December 2019 were selected as research objects. Simple random number table method was used to divide the patients into two groups, with 100 cases in each group. Two groups were given antihypertensive, hypoglycemic, antiplatelet aggregation and other conventional treatment. Control group was treated with intensive lipid-lowering and anticoagulant therapy, and observation group was treated with Buyang Huanwu Decoction for two weeks. After treatment, the effect of two groups was compared. National Institute of Health stroke scale (NIHSS) score, traditional Chinese medicine syndrome score, serum nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) level and quality of life score of two groups were recorded before and after treatment. Results Total effective rate of observation group was significantly higher than that of control group, the difference was statistically significant (P < 0.05). NIHSS score and traditional Chinese medicine syndrome score of two groups after treatment were lower than those before treatment, and observation group was lower than control group, the differences were statistically significant (P < 0.05). The levels of NGF and BDNF in two groups after treatment were higher than those before treatment, and observation group was higher than control group, the differences were statistically significant (P < 0.05). The scores of health status, physiological function, emotional function and social function of two groups after treatment were higher than those before treatment, and observation group was higher than control group, the differences were statistically significant (P < 0.05). Conclusion Buyang Huanwu Decoction combined with enhanced lipid-lowering and anticoagulation can effectively alleviate clinical symptoms of patients, inhibit the expression levels of serum NGF and BDNF, and improve the quality of life, which can be widely used in clinic.

Key words： Ischemic stroke Syndrome of qi deficiency and blood stasis Buyang Huanwu Decoction Enhanced lipid-lowering anticoagulant Quality of life

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XU Lian. Effect of Buyang Huanwu Decoction combined with enhanced lipid-lowering anticoagulant in the treatment of ischemic stroke with syndrome of qi deficiency and blood stasis[J]. 中国医药导报, 2020, 17(22): 127-130,135.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I22/127

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