血清hs-CRP、Cys C及PCT水平与肺炎心力衰竭患者预后相关性分析

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Abstract Objective To explore the relationship between the levels of serum high-sensitivity C-reactive protein (hs-CRP), cystatin C (Cys C), procalcitonin (PCT) and the prognosis of patients with pneumonia and heart failure. Methods Fifty patients with pneumonia and heart failure who admitted to the Second Affiliated Hospital of Wannan Medical College from March 2018 to June 2019 were included. The patients were followed up for six months and they were divided into good group (38 cases) and bad group (12 cases) according to the prognosis. Serum hs-CRP, Cys C and PCT levels were detected in the two groups, and the subject operating characteristic curve (ROC) was drawn to analyze the predictive value of each indicator for prognosis. The prognostic indicators of the patients were analyzed, including the changes of plasma brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and left ventricular ejection fraction (LVEF). The correlation of hs-CRP, Cys C and PCT with prognostic indicators was analyzed by Pearson correlation. Results The levels of hs-CRP, Cys C and PCT, BNP and cTnI in the good group were lower than those in the bad group, and LVEF was higher than that in the bad group (P ＜ 0.05). The AUC of hs-CRP, Cys C and PCT were 0.784, 0.723 and 0.792, respectively. The AUC of the combination of the three levels was 0.893. Serum hs-CRP, Cys C and PCT were positively correlated with plasma BNP and cTnI content (r = 0.528, 0.607, 0.596; 0.623, 0.604, 0.653, P ＜ 0.05), but negatively correlated with LVEF (r = -0.633, -0.628, -0.639, P ＜ 0.05). Conclusion The levels of hs-CRP, Cys C and PCT in patients with good prognosis of pneumonia and heart failure are significantly lower than those with poor prognosis, and they had certain predictive value for prognosis. The combined predictive effect is the best. The serum hs-CRP, Cys C and PCT levels are positively correlated with plasma BNP and cTnI levels and negatively correlated with LVEF levels.

Key words： Pneumonia and heart failure High-sensitivity C-reactive protein Cystatin C Procalcitonin

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	LU Jun1 QUAN Bin2

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LU Jun1 QUAN Bin2. Analysis of correlation between serum hs-CRP, Cys C and PCT levels and prognosis of patients with pneumonia and heart failure[J]. 中国医药导报, 2020, 17(22): 86-89.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I22/86

[1] 武冬娜，张莹，石喜习，等.重症肺炎合并心力衰竭患儿血清N末端脑钠素原、心肌肌钙蛋白I水平变化[J].中南医学科学杂志，2016，44（4）：453-456.
[2] 王敬敏，刘冬梅，徐琳，等.血浆NT-proBNP及H-FABP联合检测在小儿重症肺炎合并心力衰竭中的应用价值[J].解放军医药杂志，2017，29（9）：106-109.
[3] Mazidi M，Kengne AP，P Mikhailidis D，et al. Effects of selected dietary constituents on high-sensitivity C-reactive protein levels in U.S. adults [J]. Ann Med，2017，50（1）：1-14.
[4] 王萍，苏增锋，张颖，等.血清胱抑素C与心力衰竭的相关性研究[J].中华全科医师杂志，2017，16（6）：481-483.
[5] 庄志，朱灿宏，李蓉，等.血清降钙素原、乳酸和脑钠肽在老年社区获得性肺炎诊断和预后评估中的价值[J].医学临床研究，2017，34（5）：898-900.
[6] 中华医学会心血管病学分会.急性心力衰竭诊断和治疗指南（1）[J].中国医刊，2010，45（8）：85-89.
[7] Yap J，Fang YL，Gao F，et al. Correlation of the new york heart association classification and the 6-minute walk distance：a systematic review [J]. Clin Cardiol，2015，38（10）：621-628.
[8] 黄志俭，柯明耀，姜燕.呼吸急危重症诊疗概要[M].厦门：厦门大学出版社，2011：80-83.
[9] 李莉，李福琴，刘毅.临床常见病症急救诊疗指南[M].河南：河南大学出版社，2010：102-105.
[10] 田颖，崔玉梅.肺炎合并心力衰竭患者血浆脑钠肽和心肌肌钙蛋白I的变化及临床意义[J].医学综述，2016， 22（10）：2003-2005.
[11] Ridker PM. A test in context：High-sensitivity c-reactive protein [J]. J Am Coll Cardiol，2016，67（6）：712-723.
[12] Mirhafez SR，Ebrahimi M，Karimian MS，et al. Serum high-sensitivity C-reactive protein as a biomarker in patients with metabolic syndrome： evidence-based study with 7284 subjects [J]. Eur J Clin Nutr，2016，70（11）：1298-1304.
[13] 杨婷，曾子鉴，申永春，等.胱抑素C评估社区获得性肺炎患者严重程度及预测住院期间死亡概率的临床研究[J].华西医学，2018，33（1）：28-31.
[14] 戴红梅，朱义芳.慢性心力衰竭患者血清TNF-α、BNP、Cys-C水平与心肾功能的关系[J].中国医药导报，2019， 16（16）：155-158，162.
[15] 张小燕，杨宇.胱抑素C的临床应用及检测标准化进展[J].标记免疫分析与临床，2017，24（6）：717-720.
[16] 叶照伟，蔡立华，沈利汉，等.胱抑素C在脓毒症相关的急性肾损伤中的诊断价值[J].中国医药科学，2019，9（9）：190-193.
[17] 唐杰.血清胱抑素C在不稳定性心绞痛患者中的临床意义[J].中国医药导报，2016，13（11）：72-75.
[18] 饶平.重症肺炎患者降钙素原、C反应蛋白、外周血白细胞计数及前清蛋白的表达及意义[J].海南医学院学报，2018，24（7）：9-11.
[19] 陈淼，林晓军，张红璇，等.降钙素原和C反应蛋白在肺炎合并脓毒血症中的意义[J].中华急诊医学杂志，2017， 26（7）：807-810.
[20] 陈太碧，文英旭，邢柏，等.血清降钙素原对急性左心衰竭患者社区获得性肺炎的临床诊断研究[J].中华医院感染学杂志，2017，27（19）：4367-4370.
[21] 余升，李善高，李海红.肺炎合并心衰患儿血浆心肌肌钙蛋白与脑钠肽水平的变化情况及其与心功能的关系[J].中国妇幼保健，2015，30（5）：723-725.
[22] 杨淑霞，黄秀萍，李璐，等.NT-proBNP/BNP比值、CHE、IL-6与心力衰竭合并肺部感染患者心功能和感染指标的关系[J].成都医学院学报，2019，14（3）：363-366.
[23] 王晓垒，赵国安.慢性心力衰竭患者血浆脑钠肽、尿酸及高敏C反应蛋白水平与心肾功能的相关性[J].新乡医学院学报，2017，34（8）：762-765.