呼出气一氧化氮对支气管哮喘的诊断价值及其与疾病严重程度的关系

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Abstract Objective To investigate the diagnostic value of exhaled fractional exhaled nitric oxide (FeNO) in patients with bronchial asthma and its relationship with disease severity. Methods A total of 140 patients with suspected bronchial asthma treated in the Department of Respiratory of Shijiazhuang First Hospital from January 2015 to June 2019 were selected as observation objects. According to the test results, they were divided into 77 cases in the control group (non-bronchial asthma) and 63 cases in the observation group (bronchial asthma), the observation group was divided into 21 cases of mild group, 25 cases of moderate group, and 17 cases of severe group according to the severity of bronchial asthma. The FeNO, blood oxygen saturation (SaO2) and peak expiratory flow rate (PEF) of each group were detected. Results The FeNO in the observation group was higher than that in the control group, SaO2 and PEF were lower than those in the control group (P ＜ 0.05). FeNO level of the severe group was higher than that of the mild and moderate group, SaO2 and PEF were lower than those of the mild and moderate group (P ＜ 0.05), FeNO level of the moderate group was higher than that of the mild group, and SaO2 and PEF were lower than those of the mild group (P ＜ 0.05). Pearson correlation analysis showed that FeNO was negatively correlated with SaO2 and PEF (r = -0.171, -0.163，P = 0.032, 0.043). The best cutoff value for the diagnosis of bronchial asthma by FeNO was 46.88 μg/L, the sensitivity, specificity, positive predictive value, and negative predictive value of diagnosis were 72.36%, 91.45%, 93.07% and 75.21%, respectively. Conclusion FeNO has certain reference value in diagnosing bronchial asthma and judging the severity of the disease.

Key words： Bronchial asthma Fractional exhaled nitric oxide Diagnosis Disease severity Correlation

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	SUN Xiaoli ZHANG Xianghua CAO Xiaowei

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SUN Xiaoli ZHANG Xianghua CAO Xiaowei. The diagnostic value of fractional exhaled nitric oxide in bronchial asthma and its relationship with disease severity[J]. 中国医药导报, 2020, 17(22): 82-85.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I22/82

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