急性胰腺炎患者血浆缺血修饰白蛋白水平变化及临床意义

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Abstract Objective To investigate the changes and clinical significance of plasma ischemia-modified albumin in patients with acute pancreatitis. Methods A total of 300 patients with acute pancreatitis admitted to Panzhihua Central Hospital, Sichuan Province (hereinafter referred to as “our hospital”) from February 2017 to December 2018 were selected as the observation group, and 60 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. According to the different severity of acute pancreatitis, the observation group was divided into the mild group (95 cases), the moderate group (118 cases) and the severe group (87 cases). Plasma ischemia-modified albumin, tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) levels in each group were analyzed. The diagnostic value of ischemia-modified albumin levels in acute pancreatitis was analyzed by receiver operating characteristic (ROC) curve. Results The levels of plasma ischemia-modified albumin, TNF-α and CRP in the observation group were higher than those in the control group (P ＜ 0.05). The levels of plasma ischemia-modified albumin, TNF-α, CRP and Ranson score in the mild group were lower than those in the moderate and severe groups, and the above indexes in the moderate group were lower than those in the severe group (all P ＜ 0.05). Plasma ischemia-modified albumin was positively correlated with TNF-α, CRP and Ranson score (r = 0.464, 0.565, 0.407, P ＜ 0.05). The AUC of plasma ischaemic-modified albumin in the diagnosis of acute pancreatitis was 0.956 (95%CI: 0.937-0.976), the youden index was 0.55, the optimal cut-off value was 83.61 U/mL, the sensitivity and specificity were 82.91% and 75.21%, respectvely and the accuracy was 80.72%. Conclusion Abnormal increase of plasma ischemia-modified albumin in patients with acute pancreatitis is significantly correlated with TNF-α, CRP and Ranson score. Plasma ischemia-modified albumin has diagnostic value for the severity of acute pancreatitis.

Key words： Acute pancreatitis Ischemic-modified albumin Tumor necrosis factor-α C-reactive protein

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	WANG Yigang HUANG Ting RAN Hengquan WANG Junzhou SUN Yaxuan SUN Changqin XIONG Yong

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WANG Yigang HUANG Ting RAN Hengquan WANG Junzhou SUN Yaxuan SUN Changqin XIONG Yong. Changes and clinical significance of plasma ischemia-modified albumin in patients with acute pancreatitis[J]. 中国医药导报, 2020, 17(22): 21-24,28.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I22/21

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