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| Clinical research of Xueshuan Tongmai Decoction combined with acupuncture in the treatment of cerebral apoplexy |
| QI Chunlei TIAN Bingsheng▲ |
| Department of Rehabilitation Medicine, Affiliated Hospital of Shandong Academy of Medical Sciences, Shandong Province, Ji′nan 250031, China |
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Abstract Objective To explore clinical efficacy of Xueshuan Tongmai Decoction combined with acupuncture in the treatment of cerebral apoplexy. Methods One hundred and twenty patients with cerebral apoplexy admitted to Affiliated Hospital of Shandong Academy of Medical Sciences from January 2017 to January 2019 were selected. According to the random number table method, the patients were divided into routine group, acupuncture group and combined group, with 40 cases in each group. Routine group was treated with routine Western medicine. Acupuncture group was treated with acupuncture on the basis of routine group. Combined group was treated with Xueshuan Tongmai Decoction on the basis of acupuncture group. All three groups were treated for 3 months. Clinical efficacy was evaluated after treatment. The score of Chinese medicine symptoms, National Institute of Health stroke scale (NIHSS), Glasgow coma scale (GCS), serum nitric oxide (NO) and endothelin (ET-1) levels were compared before and after treatment. The incidence of adverse reactions during the treatment was recorded and compared among three groups. Results Total clinical effective rate of combined group was higher than that of routine group and acupuncture group (P < 0.05). After treatment, the scores of Chinese medicine symptoms (numbness of limb, spontaneous sweating, panting and weakness, dark tongue quality) in three groups were lower than those before treatment (P < 0.05); after treatment, the scores of Chinese medicine symptoms in acupuncture group and combination group were lower than those in routine group (P < 0.05); after treatment, the scores of Chinese medicine symptoms in combination group were lower than those in acupuncture group (P < 0.05). NIHSS scores of three groups after treatment were lower than those before treatment, GCS scores of three groups after treatment were higher than those before treatment (P < 0.05); NIHSS scores of acupuncture group and combination group after treatment were lower than those of routine group, GCS scores of acupuncture group and combination group after treatment were higher than those of routine group (P < 0.05); NIHSS score of combined group after treatment was lower than that of acupuncture group, GCS score of combined group after treatment was higher than that of acupuncture group (P < 0.05). After treatment, serum NO levels in three groups were higher than those before treatment, and serum ET-1 levels in three groups were lower than those before treatment (P < 0.05); serum NO levels in acupuncture group and combination group after treatment were higher than those in routine group, and serum ET-1 levels in acupuncture group and combination group after treatment were lower than those in routine group (P < 0.05); after treatment, serum NO level in combined group was higher than that in acupuncture group, and serum ET-1 level in combined group was lower than that in acupuncture group (P < 0.05). There were no serious adverse reactions during the treatment of three groups. Conclusion Xueshuan Tongmai Decoction combined with acupuncture has a significant clinical effect in treating cerebral apoplexy, which can significantly improve neurological function and vascular endothelial function damage of patients, and it has good safety.
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