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| Clinical effect of Gualou Xialing Decoction in the treatment of stable angina pectoris with coronary artery heart disease with syndrome of phlegm blocking heart vessel |
| HE Lei |
| Department of Hypertension, Ji′nan Municipal Hospital of Traditional Chinese Medicine, Shandong Province, Ji′nan 250012, China |
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Abstract Objective To observe clinical efficacy of Gualou Xialing Decoction in the treatment of stable angina pectoris of coronary artery heart disease with syndrome of phlegm blocking heart vessel. Methods From January 2018 to June 2019, 110 patients with stable angina pectoris of coronary artery heart disease with phlegm blocking heart vessel syndrome treated in Ji′nan Municipal Hospital of Traditional Chinese Medicine were selected and randomly divided into control group (50 cases) and treatment group (60 cases) by using complete randomization method. Control group was given conventional Western medicine treatment, and treatment group was given Gualou Xialing Decoction on the basis of control group. After four weeks of treatment, comprehensive curative effect, total curative effect of traditional Chinese medicine syndrome, the rate of nitroglycerin stopping and decreasing, blood homocysteine (Hcy) level, hypersensitive C-reactive protein (hs-CRP) level, fasting blood glucose, fasting insulin and insulin resistance index (HOMA2-IR) of two groups were observed. Results Total effective rate between the two groups had statistically significant difference(P ＞ 0.05). Total effective rate of traditional Chinese medicine syndrome in treatment group was higher than that in control group (P < 0.01). The stopping and decreasing rate of nitroglycerin in treatment group was significantly higher than that in control group (P < 0.05). After treatment, hs-CRP and Hcy in two groups were lower than those before treatment (P < 0.05), and treatment group was lower than that in control group (P < 0.05). After treatment, fasting insulin and HOMA2-IR in treatment group were lower than those before treatment and those in control group (P < 0.05). Conclusion Gualou Xialing Decoction combined with Western medicine has a significant effect on stable angina of coronary artery heart disease. It can significantly improve the clinical symptoms, reduce the use of nitroglycerin, reduce the level of Hcy and hs-CRP in the blood of patients, and improve the insulin resistance of patients.
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