口腔矫正器在阻塞性睡眠呼吸暂停低通气综合征合并咽喉反流中的应用效果

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Abstract Objective To investigate the clinical application effect of oral appliance in patients with obstructive sleep apnea-hypopnea syndrom (OSAHS) combined with laryngopharyngeal reflux (LPR). Methods From August 2016 to January 2018, 46 patients diagnosed as OSAHS in the Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Guangzhou Medical University were selected to receive six-month oral appliance for intervention. Polysomnography monitor and Dx-pH monitoring were performed before and after six months of the intervention respectively, and reflux symptom index (RSI) and reflux fineling score (RFS) were completed. Sleep snoring, sleep apnea hypopnea index (AHI), 24 h pH monitoring, symptoms related to LPR, RSI and RFS were compared before and after intervention. Results Before intervention, there were seventeen patients with RSI more than thirteen points and/or RFS more than seven points, while only three cases after six months of intervention. Before intervention, there were eleven patients with positive Ryan index in orthostatic and/or decubitus positions, while only two cases after six months of intervention. The AHI, snoring index, RSI, Ryan index in orthostatic position and Ryan index in decubitus position of patients were significantly lower than those before intervention, and mean oxygen saturation was significantly increased, the differences were highly statistically significant (P ＜ 0.01). Scores of multiple RSI items (persistent throat clearing, excessive sputum or nasal reflux, dyspnea or recurrent asphyxia, throat foreign body sensation) and RFS items (laryngeal mucus adhesion, diffuse laryngeal edema) were significantly lower than those before intervention, and the differences were highly statistically significant (P ＜ 0.01). Conclusion Oral appliance is helpful for the treatment of OSAHS patients combined with LPR and can significantly relieve the symptoms of patients with LPR.

Key words： Oral appliance Obstructive sleep apnea-hypopnea syndrom Laryngopharyngeal reflux Dx-pH Reflux symptom index Reflux fineling score

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	ZHANG Xiaoping CHEN Gui SONG Lijuan ZHANG Ming

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ZHANG Xiaoping CHEN Gui SONG Lijuan ZHANG Ming. Application affect of oral appliance on obstructive sleep apnea-hypopnea syndrom combined with laryngopharyngeal reflux[J]. 中国医药导报, 2020, 17(21): 125-128,144.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I21/125

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