小儿解表口服液联合小儿氨酚黄那敏颗粒治疗小儿外感发热的临床研究

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Abstract Objective To investigate the clinical efficacy and safety of Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules in the treatment of exogenous fever in children. Methods From July 2018 to April 2019, 230 children with exogenous fever who admitted to Binzhou People′s Hospital of Shandong Province were selected as objects. According to the random number table method, they were divided into control group (115 cases) and observation group (115 cases). Control group was treated with Xiaoer Paracetamol Huangnamin Granules, while observation group was treated with Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules. Both groups were given continuous treatment for three days. The clinical efficacy was evaluated after treatment. The antipyretic onset time, antipyretic time and complete antipyretic time of two groups were compared. The TCM syndrome scores and serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), γ interferon (IFN-γ) and C-reactive protein (CRP) levels were compared between two groups before and after treatment. The incidence of adverse reactions during the treatment was recorded and compared between two groups. Results The total clinical effective rate of observation group was higher than that of control group (P < 0.01). The antipyretic onset time, antipyretic time and complete antipyretic time of observation group were shorter than those of control group (all P < 0.01). There was no statistically significant difference in TCM syndrome scores between two groups before treatment (P > 0.05); TCM syndrome scores in two groups after treatment were lower than those before treatment, and observation group was lower than control group (all P < 0.01). Before treatment, there was no significant difference in serum TNF-α, IL-1β, IFN-γ and CRP levels between two groups (P > 0.05); after treatment, the levels of serum TNF-α, IL-1β, IFN-γ and CRP in two groups were lower than those before treatment, and observation group was lower than control group (all P < 0.05). During the treatment period, no serious adverse reactions occurred in both groups. Conclusion Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules has definite clinical efficacy in treating exogenous fever in children. It can shorten the antipyretic time, improve clinical symptoms and reduce the level of serum inflammatory factors, and has good safety.

Key words： Children Exogenous fever Xiaoer Jiebiao Oral Liquid Xiaoer Paracetamol Huangnamin Granules Efficacy

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	LIU Fuzhen LI Zhongying

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LIU Fuzhen LI Zhongying. Clinical study of Xiaoer Jiebiao Oral Liquid combined with Xiaoer Paracetamol Huangnamin Granules in the treatment of exogenous fever in children[J]. 中国医药导报, 2020, 17(21): 117-120.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I21/117

[1] 奚肇庆，余婉蓉，刘清泉，等.外感发热（上呼吸道感染、流行性感冒）诊疗方案[J].中国中医急症，2013，22（4）：519-520.
[2] 马艳荣. 西部部分地区外感发热（上呼吸道感染）中医证候分型的流行病学调查[D].成都：成都中医药大学，2013.
[3] 唐荣飞.银翘白虎汤加减联合布洛芬治疗小儿外感发热疗效观察[J].福建中医药，2019，50（3）：71-72.
[4] 王杰鹏，方芳，王浩，等.中医外治法治疗小儿发热应用概况[J].河北中医，2019，41（1）：146-151.
[5] 石玲婷，黄运福，李巧华.小儿解表口服液对150例风热感冒患儿的临床疗效分析[J].北方药学，2015，12（11）：141-142.
[6] 胡亚美，江载芳.诸福堂实用儿科学[M].北京：人民卫生出版社，2015：142-143.
[7] 国家中医药管理局.中医病证诊断疗效标准[M].南京：南京大学出版社，1994：226.
[8] 万英，赵相雨，李玲，等.解毒退热颗粒治疗外感发热临床观察[J].中药药理与临床，2016，32（6）：228-230.
[9] 严桂芬.退热贴联合小儿推拿治疗小儿发热的临床效果[J].当代护士：中旬刊，2019，26（11）：72-73.
[10] 赵彦昌，吴建军，张善胜，等.奥司他韦联合小儿豉翘清热颗粒治疗儿童流行性感冒的疗效观察[J].中国医药科学，2019，9（2）：38-40.
[11] 舒维萍.解表退热方药浴联合西药治疗小儿外感发热随机平行对照研究[J].实用中医内科杂志，2018，32（2）：20-22.
[12] 黄飞，刘建设.自拟柴葛解肌汤联合西药治疗小儿外感发热（肺卫风热型）的临床疗效及安全性分析[J].四川中医，2018，36（12）：63-65.
[13] 陈楠烨，郭晓涵，李慧瑜，等.小儿氨酚黄那敏颗粒解热、镇痛及抗炎的药效学研究[J].世界临床药物，2019， 40（6）：421-425，430.
[14] 尤瑞峰.小儿氨酚黄那敏退热颗粒对疱疹性咽峡炎患儿的疗效[J].深圳中西医结合杂志，2019，29（18）：127-128.
[15] 苏众祚.外感发热的中医治疗研究[J].世界最新医学信息文摘，2018，18（15）：141.
[16] 曾娟萍，袁锦权，刘志伟.小儿解表口服液联合利巴韦林注射液治疗小儿手足口病的效果观察与研究[J].海峡药学，2018，30（5）：165-166.
[17] 吴晖，邵丹，文丹，等.加减荆防败毒散治疗风寒型外感热病疗效观察及对TNF-α、IL-1β的影响[J].福建中医药，2017，48（3）：11-13.
[18] 朱洋波，韩永生，范西真.热速清颗粒联合阿莫西林治疗外感发热的疗效及对炎性反应的影响[J].世界中医药，2018，13（10）：2421-2424.
[19] 李秀玲，方步武.黄芩中7种单体成分对金黄色葡萄球菌及肺炎链球菌的体外抑菌活性研究[J].天津医科大学学报，2014，20（5）：399-401.
[20] 雷玲，李兴平，白筱璐，等.金银花抗内毒素、解热、抗炎作用研究[J].中药药理与临床，2012，28（1）：115-117.
[21] 朱军，尚兵，丁雪茹，等.液相色谱-质谱法测定金银花中噻菌灵的残留量[J].国际中医中药杂志，2018，40（3）：258-261.
[22] 庞书营.小儿解表口服液、西米替丁联合治疗小儿手足口病疗效观察[J].中国社区医师：医学专业，2012，14（17）：209-210.