白介素-6和降钙素原在低出生体重新生儿细菌感染性疾病中的预测价值

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Abstract Objective To explore the value of interleukin-6 (IL-6) and procalcitonin (PCT) to predict bacterial infection in low birth weight neonates, and provide reference to prevent and timely treatment of neonatal infection. Methods From March 2015 to March 2017, 69 neonates with low birth weight in Department of Pediatrics, Fengxian District Central Hospital of Shanghai were selected as the low birth weight neonate group, and 30 normal neonates delivered in the delivery room during the same period were selected as the normal group. According to clinical symptoms, the low birth weight neonate group were divided into suspected bacterial infection subgroup (17 cases), sepsis subgroup (6 cases) and non-infection subgroup (46 cases). White blood cell (WBC), neutrophil (Neu), C-reactive protein (CRP), PCT and IL-6 levels were measured in the normal group and the low birth weight neonate group within 4 h after admission (after admission); WBC, Neu, CRP, PCT and IL-6 levels after admission and PCT and IL-6 levels within 4 h after treatment (after treatment) were measured between different subgroups. The predictive value of ROC curve in detecting low birth weight neonates sepsis. Results The levels of PCT and IL-6 in the low birth weight neonate group after admission were higher than those in the normal group, and the differences were statistically significant (all P < 0.05). WBC, Neu and CRP levels of the two groups were not statistically significant (P > 0.05). After admission, PCT and IL-6 levels were compared among three subgroups, and the differences were statistically significant (all P < 0.05); while there were no significant differences in WBC, Neu and CRP levels among three subgroups (P > 0.05). After treatment, there were no significant differences in PCT and IL-6 levels among three subgroups (P > 0.05). ROC curve showed that the optimal critical values of PCT and IL-6 for predicting in low birth weight neonate sepsis were 2.15 ng/L and 12.34 pg/mL, sensitivity was all 83.3%, specificity were 81.0% and 71.4% respectively, and the sensitivity and specificity of the combined test were 87.3% and 83.3% respectively. Conclusion Both PCT and IL-6 test and their combined test have certain accuracy in predicting low birth weight neonate sepsis, among which combined test has the best value.

Key words： Interleukin-6 Procalcitonin Low birth weight Neonate Sepsis

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	ZHOU Wei YU Jun ZENG Xueqi JI Cuihong

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ZHOU Wei YU Jun ZENG Xueqi JI Cuihong. The value of interleukin-6 and procalcitonin to predict bacterial infection in low birth weight neonates[J]. 中国医药导报, 2020, 17(21): 109-112.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I21/109

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