联合检测血清sTNFR-1、KIM-1水平对2型糖尿病肾病的诊断能效

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Abstract Objective To explore the diagnostic value of serum soluble tumor necrosis factor receptor-1 (sTNFR-1) and kidney injury molecule-1 (KIM-1) levels in type 2 diabetic nephropathy (DN). Methods From January 2016 to January 2019, a total of 131 patients with type 2 diabetes mellitus in the First People′s Hospital of Kashgar ( hereinafter referred to as “our hospital”) were selected as the experimental group. According to the urinary microalbumin/creatinine ratio (ACR) level, they were divided into three groups: A1 group (n = 49), A2 group (n = 44), A3 group (n = 38). And healthy people in the same period in our hospital were selected as the control group (n = 30). The differences in general information, clinical laboratory indicators and serum STNFR-1 and KIM-1 among the groups were compared. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum sTNFR-1 and KIM-1 in type 2 diabetic nephropathy. Results There was significant difference in age among A1, A2 and A3 stages in the experimental group (P ＜ 0.05), and the age of the A3 group was greater than that of the A2 and A1 groups, and the age of the A2 group was greater than that of the A1 group (P ＜ 0.05). The fasting blood-glucose (FBG), ACR, sTNFR-1 and KIM-1 levels in the experimental group were significantly higher than those of the control group, and gradually increased with the increase of stages of DN, while estimation of glomerular filtration rate (eGFR) decreased gradually (all P ＜ 0.05). sTNFR-1 and KIM-1 were positively correlated with serum creatinine (SCr), urine microalbumin (UmAlb), ACR (r = 0.475, 0.468, 0.526, 0.713, 0.693, 0.714, all P ＜ 0.05), but negatively correlated with eGFR (r = -0.569, -0.721, all P ＜ 0.05). The diagnostic efficacy of combination of serum sTNFR-1 and KIM-1 in the diagnosis of DN was better than that of serum sTNFR-1 and KIM-1 alone. Conclusion The serum levels of sTNFR-1 and KIM-1 in patients with DN are significantly increased and positively correlated with the severity of the disease. The detection of serum sTNFR-1 and KIM-1 in diabetic patients is helpful to the early diagnosis and early clinical intervention of DN patients and further improving the long-term prognosis of type 2 diabetic nephropathy.

Key words： Type 2 diabetic nephropathy Soluble tumor necrosis factor receptor-1 Kidney injury molecule-1 Urinary microalbumin/creatinine ratio

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	HAN Yuming LUO Shengfang WAN Jiangli

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HAN Yuming LUO Shengfang WAN Jiangli. Diagnostic efficacy of combined detection of serum sTNFR-1 and KIM-1 levels in type 2 diabetic nephropathy[J]. 中国医药导报, 2020, 17(21): 78-81,87.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I21/78

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