口腔鳞状细胞癌发病机制及药物干预的研究进展

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Abstract Oral squamous cell carcinoma (OSCC) is an epithelial malignant tumor, which mainly occurs in maxillofacial skin and oral mucosa. The formation of OSCC results from multiple gene mutations, but its pathogenesis has not been fully elucidated. The mutations of p16, p53, c-erbB-2 and Bmi-1 genes are closely related to the occurrence and development of OSCC. Traditional Chinese herbal medicine extracts, such as wogonin, curcumin, licorice chalcone, and the immunosuppressant drug rapamycin have certain inhibitory effect on OSCC. This article reviews the pathogenesis of OSCC and drug intervention, which provides a theoretical basis for the research and treatment of OSCC.

Key words： Oral squamous cell carcinoma Pathogenesis Drug intervention

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	LI Weibo1 CAO Juan1 LIU Luyao1 ZHANG Wenwen1 ZHENG Shize1 DONG Chunling2 LI Bo1

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LI Weibo1 CAO Juan1 LIU Luyao1 ZHANG Wenwen1 ZHENG Shize1 DONG Chunling2 LI Bo1. Research progress on pathogenesis and drug intervention of oral squamous cell carcinoma[J]. 中国医药导报, 2020, 17(21): 42-45.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I21/42

[1] Guo J，Wen N，Yang SF，et al. MiR-92a regulates oral squamous cell carcinoma（OSCC） cell growth by targeting FOXP1 expression [J]. Biomed Pharmacother，2018，104：77-86.
[2] Yan LJ，Chen F，Liu FQ，et al. Differences in modifiable factors of oral squamous cell carcinoma in the upper and lower of oral fissure [J]. Oncotarget，2017，8（43）：75094-75101.
[3] Rivera C. Essentials of oral cancer [J]. Int J Clin Exp Pathol，2015，8（9）：11884-11894.
[4] Zanoni DK，Montero PH，Migliacci JC，et al. Survival outcomes after treatment of cancer of the oral cavity（1985-2015） [J]. Oral Oncol，2019，90：115-121.
[5] Ernani V，Saba NF. Oral cavity cancer：risk factors，pathology，and management [J]. Oncology，2015，89（4）：187-195.
[6] Ishibashi N，Yamagata K，Sasaki H，et al. Real-time tissue elastography for the diagnosis of lymph node metastasis in oral squamous cell carcinoma [J]. Ultrasound Med Biol，2012，38（3）：389-395.
[7] Xing XB，Cai WB，Luo L，et al. The prognostic value of p16 hypermethylation in cancer：a meta-analysis [J]. PLoS One，2013，8（6）：8.
[8] Sedghizadeh PP，Billington WD，Paxton D，et al. Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis [J]. Oral Oncol，2016，54：15-27.
[9] de Vicente JC，Gutierrez LMJ，Zapatero AH，et al. Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastases [J]. Head Neck，2004，26（1）：22-30.
[10] Arnaiz E，Sole C，Manterola L，et al. CircRNAs and cancer：biomarkers and master regulators [J]. Semin Cancer Biol，2019，58：90-99.
[11] Su W，Sun S，Wang F，et al. Circular RNA hsa_circ_ 0055538 regulates the malignant biological behavior of oral squamous cell carcinoma through the p53/Bcl-2/caspase signaling pathway [J]. J Transl Med，2019，17（1）：76.
[12] Mahlknecht G，Maron R，Mancini M，et al. Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth [J]. Pro Natl Acad Sci U S A，2013，110（20）：8170-8175.
[13] Xia WY，Lau YK，Zhang HZ，et al. Combination of EGFR，HER-2/neu，and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members [J]. Clin Cancer Res，1999，5（12）：4164-4174.
[14] Allegra E，Caltabiano R，Amorosi A，et al. Expression of BMI1 and p16 in laryngeal squamous cell carcinoma [J]. Head Neck，2013，35（6）：847-851.
[15] Kang MK，Kim RH，Kim SJ，et al. Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival [J]. Br J Cancer，2007，96（1）：126-133.
[16] Wang Y，Yin RF，Teng JS. Wogonoside induces cell cycle arrest and mitochondrial mediated apoptosis by modulation of Bcl-2 and Bax in osteosarcoma cancer cells [J]. Int J Clin Exp Pathol，2015，8（1）：63-72.
[17] Sun Y，Zhao Y，Wang XP，et al. Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-kappa B activation through PI3K/Akt pathway [J]. Oncotarget，2016，7（23）：34300-34315.
[18] Zhang L，Wang HD，Cong ZX，et al. Wogonoside induces autophagy-related apoptosis in human glioblastoma cells [J]. Oncol Rep，2014，32（3）：1179-1187.
[19] Zhu LM，Tang Y，Wang ZZ，et al. Wogonin inhibited oral squamous cell carcinoma cells proliferation and invasion through modulation of the Wnt/beta-catenin signaling pathway [J]. J Biomater Tissue Eng，2018，8（10）：1399-1409.
[20] Guertin DA，Sabatini DM. Defining the role of mTOR in cancer [J]. Cancer Cell，2007，12（1）：9-22.
[21] Owonikoko TK. Inhibitors of mTOR pathway for cancer therapy，moving on from rapalogs to TORKinibs [J]. Cancer，2015，121（19）：3390-3392.
[22] Abdollahi E，Momtazi AA，Johnston TP，et al. Therapeutic effects of curcumin in inflammatory and immune-mediated diseases：a nature-made jack-of-all-trades? [J]. J Cell Physiol，2018，233（2）：830-848.
[23] Mirzaei H，Naseri G，Rezaee R，et al. Curcumin：a new candidate for melanoma therapy? [J]. Int J Cancer，2016， 139（8）：1683-1695.
[24] Ke J，Ma P，Chen JP，et al. LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway [J]. Onco Targets Ther，2018，11：3025-3033.
[25] Bi QJ，Men XJ，Han R，et al. LHX6 inhibits the proliferation，invasion and migration of breast cancer cells by modulating the PI3K/Akt/mTOR signaling pathway [J]. Eur Rev Med Pharmacol Sci，2018，22（10）：3067-3073.
[26] de Campos PS，Matte BF，Diel LF，et al. Low doses of curcuma longa modulates cell migration and cell-cell adhesion [J]. Phytother Res，2017，31（9）：1433-1440.
[27] Sharma C，Kaur J，Shishodia S，et al. Curcumin down regulates smokeless tobacco-induced NF-kappa B activation and COX-2 expression in human oral premalignant and cancer cells [J]. Toxicology，2006，228（1）：1-15.
[28] Siddappa G，Kulsum S，Ravindra DR，et al. Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells [J]. Mol Carcinog，2017，56（11）：2446-2460.
[29] Xiao XY，Hao MA，Yang XY，et al. Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis [J]. Cancer Lett，2011，302（1）：69-75.
[30] Dao TT，Nguyen PH，Lee HS，et al. Chalcones as novel influenza A（H1N1）neuraminidase inhibitors from Glycyrrhiza inflata [J]. Bioorg Med Chem Lett，2011，21（1）：294-298.
[31] Seo JH，Choi HW，Oh HN，et al. Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma [J]. J Cell Physiol，2019，234（2）：1780-1793.
[32] Nho SH，Yoon G，Seo JH，et al. Licochalcone H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3 [J]. Oncol Rep，2019，41（1）：333-340.
[33] Oh HN，Oh KB，Lee MH，et al. JAK2 regulation by licochalcone H inhibits the cell growth and induces apoptosis in oral squamous cell carcinoma [J]. Phytomedicine，2019，52：60-69.