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| Research progress of TAM receptors and its signaling pathways in immune regulation |
| XIE Lihong1 WANG Baojun2▲ |
| 1.Department of Neurology, Baotou Clinical Medical College, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Baotou 014040, China; 2.Department of Neurology, Center Hospital of Baotou, Inner Mongolia Autonomous Region, Baotou 014040, China |
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Abstract TAM receptor is a subfamily of receptor tyrosinase, including three members Tyro3, Axl and Mertk. The common ligands of the TAM receptors are growth arrest specific gene 6 (Gas6) and S protein (ProS1). TAM receptors and ligands are widely expressed in mammalian immune, blood, reproductive, circulatory and nervous systems, and have many biological functions, such as inhibiting cell apoptosis, promoting cell proliferation, mediating cell adhesion, migration, phagocytic apoptotic cells, and participating in immune regulation. TAM receptors andits ligands play an important role in autoimmune diseases.
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