黄连素联合四联疗法在幽门螺杆菌一线治疗中的作用研究

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Abstract Objective To investigate the efficacy and safety of Berberine combined with Quadruple therapy as a primary therapy for Helicobacter pylori（Hp） eradication. Methods A total of 100 Hp infected patients with chronic gastritis diagnosed by gastroscopy were enrolled in Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from November 2018 to November 2019. They were divided into the experimental group and the control group by random number table method, with 50 cases in each group. The control group was treated with Quadruple therapy，while the experimental group was treated with Berberine on the basis of the control group． The curative effect, eradication rate and adverse reactions of two groups were assessed. The drug resistance of Hp were tested for three common antibiotics by the agar dilution method, and the effect of antibiotic resistance on the eradication rate of the two groups was analyzed. Results According to the treatment intention analysis, the Hp eradication rate in the experimental group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05); according to the per-protocol analysis, there was no statistically significant difference in Hp eradication rate between the two groups (P ＞ 0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05), and the incidence of nausea and diarrhea in the experimental group was significantly lower than that in the control group (P ＜ 0.05). The resistant rates of Hp to Clarithromycin, Metronidazole and Amoxicillin were 32.0%, 64.0%, 0.0%, respectively. The eradication rate of the experimental group was significantly higher than that in the control group in patients with clarithromycin-resistant strains (P ＜ 0.05). Conclusion Berberine combined with Quadruple therapy can increase the eradication rate of Hp and has high safety. It can be used as an option for first-line treatment in areas with high resistance to Hp Clarithromycin.

Key words： Helicobacter pylori Quadruple therapy Berberine Clarithromycin Drug resistance

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	XU Xiaoqing ZHOU Fan WU Xiaoxi LU Juan CAO Qin

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XU Xiaoqing ZHOU Fan WU Xiaoxi LU Juan CAO Qin. Study on the role of Berberine combined with Quadruple therapy in initial Helicobacter pylori eradication [J]. 中国医药导报, 2020, 17(19): 78-81.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I19/78

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