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| Research progress of caspase-1 in ocular disease |
| LI Huazhang1 LI Zhijian2 |
1.Department of Ophthalmology, the First Clinical Medical College, Harbin Medical University, Heilongjiang Province, Harbin 150086, China;
2.the Third Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150001, China |
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Abstract Cysteinyl aspartate specific proteinase-1 (caspase-1) as an inflammation regulator has been shown to be a key link in inflammation regulation and cell apoptosis. A large number of studies have shown that caspase-1 is widely involved in the molecular mechanisms of cardiovascular diseases, metabolic diseases and liver cirrhosis and other systemic diseases. Caspase-1 is also closely related to the occurrence of a variety of ophthalmic diseases, and plays an important role in common diseases such as age-related cataracts, age-related macular degeneration and diabetic retinopathy. This article mainly summarizes the role of caspase-1 in the above diseases.
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