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| Retrospective analysis of adverse reactions of nervous system caused by antibiotics |
| XU Bingfa1 QIN Kan1 SUN Jing1 REN Tingting2 SUN Wanlu3 TAI Hui4 WEN Gang5 |
1.Department of Pharmacy, the Third Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei 230061, China;
2.Department of Pharmacy, Lujiang County People′s Hospital, Anhui Province, Lujiang 231500, China;
3.Department of Pharmacy, Funan County People′s Hospital, Anhui Province, Funan 236300, China;
4.Department of Pharmacy, Biyang County People′s Hospital, He′nan Province, Biyang 463700, China;
5.Department of Gastroenterology, the Third Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei 230061, China |
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Abstract Objective To investigate the occurrence and risk factors of nervous system adverse reaction induced by antibiotics. Methods The adverse drug reaction (ADR) reported in the Third Affiliated Hospital of Anhui Medical University from January 2003 to June 2019 were analyzed, including 103 cases of neurological adverse reactions related to antibiotics. The gender, age, time of occurrence of ADR, dosage, dosage form, mode of administration and combination of drugs were analyzed. Results The rate of over 70 years old was the highest in 103 patients (33.0%). The most common antibiotics causing adverse reactions of nervous system were fluoroquinolones (49.1%), cephalosporins (14.2%), macrolides (9.4%), triazoles (8.5%), the incidence of Clindamycin, Voriconazole and Moxifloxacin was the highest among the single cultivars. ADR of nervous system mainly occurred within one day after administration (87.7%). Conclusion The ADR of nervous system caused by antibiotics should be paid enough attention. Careful selection of antibiotics, individualized administration and intensive drug monitoring are essential to reduce the adverse reactions of nervous system.
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