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| Clinical effect of modified Shenzhe Peiqi Decoction in treatment of esophageal low-grade intraepithelial neoplasia |
| YANG Sishi JIANG Chao SHAO Yingxin |
| Department of Spleen and Stomach Diseases, Huanggang Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine, Hubei Province, Huanggang 438000, China |
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Abstract Objective To observe clinical effect of modified Shenzhe Peiqi Decoction in the treatment of esophageal low grade intraepithelial neoplasia. Methods Fifty patients with esophageal low grade intraepithelial neoplasia from January 2017 to January 2018 in the Outpatient and Inpatient of Spleen and Stomach Department of Huanggang Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine were selected and divided into control group and treatment group by using random number table method, with 25 cases in each group. Control group was given Western medicine to inhibit acid and protect stomach. Treatment group was given modified Shenzhe Peiqi Decoction orally for 8 weeks. Before treatment and 1, 2, 4 and 8 weeks after treatment, total score of traditional Chinese medicine syndrome rating scale was used to determine the curative effect of traditional Chinese medicine syndrome. At the end of the course of treatment, 4 weeks after the drug was stopped, electronic gastroscopy was performed again. The endoscopic and histopathological manifestations were statistically analyzed, and the improvement degree of pathological manifestations and total scores were calculated. All patients were followed up for 24 weeks to find out whether there was any change of the condition. Results The effects of traditional Chinese medicine syndrome, endoscopic esophageal mucosa and histopathology in treatment group were better than those in control group, the differences were statistically significant (P < 0.05). Conclusion Modified Shenzhe Peiqi Decoction has an ideal effect in the treatment of esophageal low grade intraepithelial neoplasia, it can improve the reversal rate of esophageal low grade intraepithelial neoplasia, avoid excessive treatment of various minimally invasive therapies under endoscope, and effectively control the occurrence of esophageal cancer.
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