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| Relationship between coagulation parameters and tumor markers and venous thromboembolism in different stages of malignant tumors |
| HE Lili CAO Guolei LUO Qin▲ |
| Department of Integrated Internal Medicine, the Third Clinical Medical College, Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China |
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Abstract Objective To explore the relationship between coagulation parameters and tumor markers and venous thromboembolism (VTE) in different stages of malignant tumors. Methods A total of 233 patients with malignant tumors complicated with VTE who admitted to the Third Clinical Medical College of Xinjiang Medical University from May 2013 to January 2017 were selected as research objects. According to the malignant tumor TNM staging criteria, they were divided into group Ⅰ (17 cases), group Ⅱ (17 cases), group Ⅲ (54 cases), group Ⅳ (145 cases). D-dimer (D-D), prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (Fbg), international normalized ration (INR) and Glycan 19-9 (CA19-9), CA125, Carcinoembryonic Antigen (CEA) were compared between four groups. Results D-D value in group Ⅲ was higher than that in groupⅠ-Ⅱ (P < 0.05); D-D value in group Ⅳ was higher than that in group Ⅰ-Ⅲ (P < 0.05); and there were no significant differences in PT, APTT, Fbg, INR levels between four groups (P > 0.05). CA19-9 levels in group Ⅲ were higher than those in group Ⅱ (P < 0.05); CA19-9, CA125 levels in group Ⅳ were higher than those in group Ⅰ-Ⅲ (P < 0.05); CEA levels in group Ⅲ-Ⅳ were higher than those in group Ⅰ-Ⅱ (P < 0.05). Conclusion Patients with late stage should pay more attention to D-D and CA19-9, CA125 and CEA levels, and the detection frequency can be appropriately increased to monitor their thrombus status.
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