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| Study on the new model of thyroid function screening before pregnancy |
| DING Xufeng1* HU Yuqing2* MA Niandi1 MA Wei2 FAN Jun3 |
1.Department of Reproductive Health, Maternal and Child Health Care Hospital of Yixing, Jiangsu Province, Wuxi 214200, China;
2.Department of Medical Laboratory, Maternal and Child Health Care Hospital of Yixing, Jiangsu Province, Wuxi 214200, China;
3.Jiangsu Institute of Nuclear Medicine, Jiangsu Province, Wuxi 214063, China |
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Abstract Objective To explore the potentiality of a new thyroid function screening before pregnancy. Methods A total of 1026 females came from Maternal and Child Health Care Hospital of Yixing and prepared for pregnancy were enrolled. The concentrations of serum TPOAb and TgAb were detected by TRFIA in 719 cases whose TSH between 0.1-2.5 mU/L. Results of TRFIA were confirmed by Roche electrochemical luminescence, and the coincidence rate between TRFIA test and Roche electrochemical luminescence was observed. Results Among the 719 patients, TRFIA detected more TPOAb positive in 36 cases, accounting for 5.01%. TgAb positive in 31 cases, accounting for 4.31%. Of the 36 patients with positive TPOAb, 18 patients were confirmed by the project funds, 12 patients were confirmed by outpatient self-funded, and 6 patients refused to be reviewed. Among the 31 patients with positive TgAb, 15 patients were confirmed by the project funds, 13 patients were confirmed by outpatient self-funded, and 3 patients refused to be reviewed. Both of the project funds and the outpatient self-funded verification results showed that, the positive rate of thyroid antibody detected by TRFIA was highly consisted with that of Roche electrochemical luminescence method, the compliance rates of TRFIA and ECLIA on TPOAb were 94.44% and 91.67%, respectively, and those of TgAb were 93.33% and 84.62%, respectively. Conclusion The accuracy of TRFIA is relatively high. The new mode is conducive to the early discovery of TPOAb and TgAb in thyroid function screening of women before pregnancy, and it helps to promote bear and rear better children.
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