干细胞移植对卒中后功能重构的网状meta分析

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Abstract Objective To review the effect of stem cell transplantation in the treatment of neurologic deficit and different methods of cell transplantationon functional remodeling after stroke. Methods Control trails about the effect of stem cell transplantation on after neurologic deficitstroke were searched and evaluated from PubMed, EMbase, Medline, the Cochrane library, CNKI and WanFang, VIP database. The retrieval time was from the database to May 2019. After screening and evaluating the literatures according to the inclusion criteria, the national institutes of health stroke scale (NIHSS) scores of each group were extracted for combined analysis. Results A total of 11 studies with 567 participants totally were included. The results of direct meta-analysis showed that the scores of NIHSS in the experinrental group(stem cell transplantation) was higher than the control group(normal saline or conventional treatment), the difference was statistically significant (MD = -2.37,95%CI：[-2.79，-1.97], P ＜ 0.05). The results of network meta-analysis showed the efficacy of different cell transplantation methods: arterial ＞ vein + other way ＞ non-venous transplantation ＞ vein and different period: acute ＞ chronic. Conclusion Stem cell transplantation is beneficial to improve the impaired function for stroke patients, andthedifferent way and time of cell transplantation can affect the recovery of nerve function.

Key words： Stroke Stem cell transplantation Functional deficit Meta-analysis

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	WANG Lulu GAO Run LIU Li

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WANG Lulu GAO Run LIU Li. The effect of stem cell transplantation on functional remodeling after stroke : a network meta-analysis[J]. 中国医药导报, 2020, 17(17): 91-95.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I17/91

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