超声造影定量分析技术在慢性肾脏病早期的应用价值

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Abstract Objective To investigate the application value of quantitative contrast-enhanced ultrasound in early stage of chronic kidney disease (CKD). Methods A total of 51 cases of CKD patients who underwent kidney contrast-enhanced ultrasound in Xuanwu Hospital, Capital Medical University from August 2018 to October 2019 were selected as the study subjects. According to the clinical practice guidelines for CKD, They were divided into three groups, including 17 patients in group 1 (stage 1 CKD), 17 patients in group 2 (stage 2 CKD), and 17 patients in group 3 (stage 3-5 CKD). Kidney size， segmental renal artery peak systolic velocity (PSV)，resistance index (RI), contrast-enhanced ultrasound parameters such as arrival time (AT), slope of ascending branches (A), time to peak (TTP), derived peak intensity (DPI), slope of descending branches α (α), area under the curve (AUC), and serum creatinine and urea nitrogen levels in three groups were analyzed. Results Serum creatinine and urea nitrogen levels in group 1 and group 2 were lower than those in group 3 (P < 0.05). There were no statistically significant differences in serum creatinine and urea nitrogen levels between group 1 and group 2 (P > 0.05). Cortical thickness and PSV of segmental renal artery in group 1 and group 2 were higher than those in group 3 (all P < 0.05), and there were no significant differences in cortical thickness and PSV of segmental renal artery between group 1 and group 2 (P > 0.05). DPI and AUC of group 1 were lower than those of group 2, and DPI and AUC of group 2 were higher than those of group 3 (all P < 0.05) and there were no significant differences in DPI and AUC between group 1 and group 3 (P > 0.05). Conclusion Quantitative renal contrast-enhanced ultrasound can be used for real-time monitoring of renal cortical blood perfusion, which can provide objective indicators for the assessment of renal function in patients with CKD. Especially in the early stage of CKD, the changes in CKD are more sensitive than those in common laboratory indexes such as blood creatinine and urea nitrogen, which is helpful for the early diagnosis and treatment of CKD in clinic.

Key words： Chronic kidney disease Kidney contrast-enhanced ultrasound Kidney cortical thickness Segmental renal artery peak systolic velocity

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	REN Jiaming1 LENG Zhenpeng1 YANG Jingchun1 LIU Hua2 CHANG Ying1 WANG Pan1

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REN Jiaming1 LENG Zhenpeng1 YANG Jingchun1 LIU Hua2 CHANG Ying1 WANG Pan1. Application value of quantitative contrast-enhanced ultrasound in the early stage of chronic kidney disease[J]. 中国医药导报, 2020, 17(16): 143-146,155.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I16/143

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