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| Application effect of sedation and analgesia with Fentanyl and Midazolam in modified percutaneous tracheostomy for severe patients in neurosurgery |
| DU Xiuyu1 ZHAI Xiaodong1 LIU Zhi1 LI Yuanli2 YANG Jing1 SUN Zhiqiang1 YANG Xiaohong1 GAO Fei3 |
1.Department of Neurosurgery (Ward 15), the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of Intensive Care Unit, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
3.Department of Emergency Intensive Care Unit, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China |
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Abstract Objective To evaluate the application effect of sedation and analgesia with Fentanyl and Midazolam in modified percutaneous tracheostomy for severe patients in neurosurgery. Methods Clinical data of 71 patients whom underwent modified percutaneous tracheostomy in the First Affiliated Hospital of Hebei North University were collected from June 2018 to September 2019. They were divided into two groups according to the drugs for sedation and analgesia randomly, Fentanyl and Midazolam were used in the observation group (n = 36) and Diazepam or lytic cocktail were used in the control group (n = 35). The operation time, blood oxygen saturation, tracheal stimulus response, intraoperative and postoperative bleeding volume were compared between the two groups. Results There was no statistically significance in operation time of two groups (P > 0.05). There were no significant differences in intraoperative and postoperative bleeding volume of the two groups (P > 0.05). Tracheal stimulus response of observation group was weaker than control group, the difference was statistically significant (P < 0.01). Blood oxygen saturation in observation group was higher than that in control group, the difference was statistically significant (P < 0.01). No operation related death or pneumothorax case in two groups. Conclusion Sedative and analgesic therapy with Fentanyl and Midazolam can reduce tracheal stimulus response and maintain a stable blood oxygen saturation in modified percutaneous tracheostomy effectively, and it is a safer procedure.
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