静脉输注利多卡因在无痛纤维支气管镜检查中的应用

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Abstract Objective To investigate the effects of intravenous Lidocaine on the amount of Propofol during painless fiberoptic bronchoscopy and postoperative recovery. Methods From March 2019 to January 2020, a total of 100 patients undergoing painless fiberoptic bronchoscopy in the First Affiliated Hospital of Anhui Medical University were enrolled as the subjects. According to the random number table method, they were divided into control group and Lidocaine group, with 50 cases in each group. In the Lidocaine group, 1.5 mg/kg Lidocaine was intravenously injected during anesthesia induction, and the infusion was continued at a rate of 2 mg/（kg·h） until the end of the examination, while the control group was given the same amount of normal saline. The dose and total amount of Propofol induction, the changes of vital signs at different points during the perioperative period, the quality of recovery 40 (QoR-40) score 1 day before operation and 1 day after operation, the incidence of postoperative nausea and vomiting in the two groups were recorded. Results The total amount of Propofol in the Lidocaine group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). At T1 points, the heart rate (HR) and mean arterial pressure (MAP) of the control group were higher than those of T0 points, while the Lidocaine group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). In addition, HR and MAP interacted between groups (P ＜ 0.05). At T1 and T2 points, pulse oxygen saturation in two groups were higher than those in T0 points, and the differences were statistically significant (P ＜ 0.05). The score of mood state, physical comfort, pain and total score of the QoR-40 scale in the Lidocaine group on 1 d postoperatively were significantly higher than those in the control group (P ＜ 0.05). The incidence of nausea and vomiting in the control group was significantly higher than that in the Lidocaine group, and the difference was statistically significant (χ2=5.01, P < 0.05). Conclusion Intravenous Lidocaine in painless bronchoscopy could reduce Propofol requirement and the incidence of nausea and vomiting after operation, and accelerate post-bronchoscopy recovery.

Key words： Lidocaine Intravenous infusion Postoperative recovery Propofol

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	YANG Xiuli LI Yuanhai

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YANG Xiuli LI Yuanhai. Application of intravenous Lidocaine in painless fiberoptic bronchoscopy[J]. 中国医药导报, 2020, 17(16): 105-108.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I16/105

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