不同糖耐量人群体重指数、血脂、胰岛素抵抗与血清alarin水平相关性研究

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Abstract Objective To investigate the body mass index(BMI), blood lipids, insulin resistance (IR) and serum alarin levels among different glucose tolerance population. Methods A total of 124 people who underwent oral glucose tolerance test (OGTT) in Qinhuangdao Cerebrovascular Disease Hospital of Hebei Province from June 2017 to June 2019 were selected as the study subjects. According to the results of OGTT, they were divided into 43 cases in type 2 diabetes (T2DM) group, 36 cases in impaired glucose tolerance group and 45 people in normal group. The height and weight of the study subjects were measured, Blood lipids, serum alarin, fasting plasma glucose (FPG) and fasting insulin (FINS) were detected and BMI, homeostasis model insulin resistance index (HOMR-IR) and homeostasis model assessment-β (HOMA-β) were calculated. Results The differences of levels of alarin, BMI, triacylglycerol (TG), total cholesterol (TC), HOMR-IR and HOMA-β were statistically significant in three groups (P < 0.05). TC levels in T2DM group and impaired glucose tolerance group were lower than those in normal group and levels of alarin, BMI and TG were higher than those in normal group (P < 0.05). The levels of alarin and TG in T2DM group were higher than those in impaired glucose tolerance group (P < 0.05). The HOMR-IR in T2DM group and impaired glucose tolerance group were higher than those in normal group (P < 0.05), and T2DM group was higher than impaired glucose tolerance group (P < 0.05). HOMA-β of T2DM group was lower than that of impaired glucose tolerance group and normal group (P < 0.05). Serum alarin levels were positively correlated with BMI, TG and HOMR-IR (r =0.239, 0.367, 0.681, P < 0.05), and negatively correlated with HOMA-β (r = -0.323, P < 0.05). Conclusion Alarin, BMI, blood lipids and IR are different in different glucose tolerance population. Alarin is associated with BMI, blood lipids, and IR.

Key words： Alarin Type 2 diabetes mellitus Insulin resistance Body mass index Blood lipid

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	YANG Ru CAO Xinyu WANG Qian

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YANG Ru CAO Xinyu WANG Qian. Study on the correlation between body mass index, blood lipids, insulin resistance and serum alarin in different glucose tolerance population[J]. 中国医药导报, 2020, 17(16): 94-96,100.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I16/94

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