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| Clinical observation of Anisodamine Hydrobromide Injection on the excretion of small common bile duct stones |
| LYU Haopeng1 SONG Wenjiu1 PENG Wei2 WEN Tianfu2 LI Chuan2 |
1.Department of General Surgery, Xinjin Branch of the Sichuan Provincial People′s Hospital, Sichuan Province, Xinjin 611430, China;
2.Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, Sichuan Province, Chengdu 610041, China |
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Abstract Objective To observe the effect of Anisodamine Hydrobromide Injection on the excretion of single symptomatic common bile duct (CBD) stones with diameter ≤10 mm. Methods A retrospective analysis was performed on the stone discharge of 127 patients with single symptomatic CBD stones with diameter ≤10 mm diagnosed in the Department of General Surgery, Xinjin Branch of the Sichuan Provincial People′s Hospital, from September 2016 to June 2019. Among them, sixty-eight patients who received of Anisodamine Hydrobromide Injection were included in the experimental group. Fifty-nine patients who did not receive Anisodamine Hydrobromide Injection were treated as the control group. In the experimental group, Anisodamine Hydrobromide Injection was added on the basis of general treatment, 10 mg/time, intravenous injection, q6h, continuous use for 12 days. The control group received only general treatment. The discharge rate and adverse reactions of CBD stones in the two groups were compared. Results The discharge rate of 6 day and total discharge rate of CBD stones in the experimental group were higher than those in the control group, with statistically significant differences (P ＜ 0.05 or P ＜ 0.01). The discharge rate of CBD stones with diameter ＜ 5 mm in the experimental group was higher than that in the control group, and the difference was highly statistically significant (P ＜ 0.01). There was no statistically significant difference in the discharge rate of CBD stones with a diameter of 5-10 mm between the experimental group and the control group (P ＞ 0.05). In the experimental group, the rate of promoting the discharge of CBD stones with a diameter of ＜ 5 mm was higher than that of CBD stones with a diameter of 5-10 mm, and the difference was highly statistically significant (P ＜ 0.01). There was no significant difference in self-discharge rate between the CBD stones with a diameter of ＜ 5 mm and CBD stones with a diameter of 5-10 mm in the control group (P ＞ 0.05). In the experimental group, 8 patients presented with flushing and dry mouth, but no other adverse reactions were observed. The difference of adverse reactions between the two groups was statistically significant (P ＜ 0.05). Conclusion Anisodamine Hydrobromide Injection has the effect of promoting the discharge of single symptomatic CBD stones with the diameter ≤10 mm, especially for CBD stones with the diameter ＜5 mm, which is of good safety.
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