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| Study on the rule of traditional Chinese medicine in the treatment of radiation dermatitis based on data mining |
| WANG Qing1，2 WU Xianwen2 HE Jian3 WANG Shan1，2 YUE Jiajia1，2 CAI Linlin2 |
1.School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;
3.Office of Drug Clinical Trial Organization, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China |
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Abstract Objective To explore and discuss the therapeutic rules and characteristics of traditional Chinese medicine external prescription for radioactive dermatitis. Methods The literatures of CNKI, Wanfang data knowledge service platform, and VIP database (from July 1977 to September 2019) were searched by computer. The literatures related to external treatment of radioactive dermatitis by traditional Chinese medicine were collected and sorted out. Traditional Chinese medicine inheritance support system software (V2.5) was applied to establish a unified standard prescription database, and relevant data mining was carried out. Results Through screening, 61 formula of traditional Chinese medicine external treatment for radioactive dermatitis were obtained. Among them, 76 medicinal herbs were involved, among which, cold and warm medicinal herbs, bitter and sweet medicinal herbs account for a larger proportion, and liver, spleen and heart meridians were the ones with a higher frequency of meridian return. The top three drugs used in frequency were Borneolum Syntheticum, Cortex Phellodendri, Radix Lithospermi, the most frequently used drug combination was Borneolum Syntheticum-Cortex Phellodendri, Borneolum Syntheticum-Radix Lithospermi, Radix Scutellariae-Cortex Phellodendri, Rhizoma Coptidis-Cortex Phellodendri, excavating 10 core drug combinations and 5 new prescriptions. Conclusion The currently known prescriptions for the treatment of radiation dermatitis are mainly for clearing away heat-evil and dispelling dampness, cooling blood, detoxifying and relieving pain, as well as promoting granulation and astringing sores, benefiting qi and nourishing yin, etc. The core drug group and new prescription can provide reference for theoretical research, new drug development and clinical treatment of radioactive dermatitis.
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