基于关联规则与聚类分析探索中药外治手足综合征的用药规律

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Abstract Objective To search and analyze medication rules of traditional Chinese medicine (TCM) for hand foot syndrome (HFS). Methods Articles were searched from CNKI, Wanfang data and VIP network by the words of “hand foot syndrome” or “hand foot skin reaction” before September 2019. The formulas of external use for HFS was screened, and the data was logged in excel 2019. The association rules were conducted using “arules” of R 3.6.0 to search for TCM composition with strong association and cluster analysis was conducted by SPSS 20.0 for herbs of high frequency to research main combination of TCM for HFS. Results Eighty TCM formulas was included. There were 15 herbs that using frequency was more than 10. According to medication rules, 11 herb-partners had strong combination. Herbs which had the most strong internal relationship were Radix Astragali seu Hedysari, Flos Carthami, Ramulus Cinnamomi, Radix Angelicae Sinensis. Cluster analysis produced two main treatment aspects: benefiting qi for activating blood circulation, warming womb and channels and dredging channels. Conclusion The external application of TCM in treating HFS is mainly through benefiting qi for activating blood circulation, warming womb and channels and dredging channels, as well as clearing heat and removing toxicity and nourishing blood for moistening dryness.

Key words： Herbal formula External treatment Hand foot syndrome Association rules Data mining Regularity of herbal medicine

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	YU Ran1
	2 JIA Liqun2 LOU Yanni2▲

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YU Ran1,2 JIA Liqun2 LOU Yanni2▲. Exploration on the rule of traditional Chinese medicine in external treatment of hand foot syndrome based on association rule and cluster analysis[J]. 中国医药导报, 2020, 17(15): 139-142.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I15/139

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