|
|
|
| Analysis on prescription rules of oral prescription for malignant pleural effusion based on data mining |
| JIA Hainü1 ZHANG Yi1 ZHOU Mengling2 LYU Mingsheng3 GAO Weihua4 LI Wenzhe5 YAN Jun1 |
1.Department of Respiration, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
2.Department of Encephalology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
3.Department of Respiration, the Third Hospital of Beijing University of Chinese Medicine, Beijing 100191, China;
4.Department of Nephropathy, the Third Hospital of Beijing University of Chinese Medicine, Beijing 100191, China;
5.Department of Internal Medicine, Nankou Hospital of Changping District in Beijing City, Beijing 102202, China |
|
|
|
Abstract Objective To conclude and summarize composing law of traditional Chinese medicine formulation for oral administration in treating malignant pleural effusion (MPE) based on data mining. Methods The related literatures of traditional Chinese medicine treating MPE from August 2009 to July 2019 were searched in CNKI. The internal prescriptions of literatures were screened. The medicinal properties, frequency of medication and new prescriptions of that internal prescriptions was sorted and analyzed by a software named “Chinese medicine inheritance support system”. Results One hundred and twenty-seven oral prescriptions treating MPE and 220 herbs were screened; the most frequent four nature and five flavour of drugs was wen and gan. “Semen Descurainiae”, “Poria”, “Fructus Jujubae”, “Ramulus Cinnamomi”, “Radix Astragali seu Hedysari”, “Rhizoma Atractylodis Macrocephalae” were more frequent used in herbs. A total of 28 commonly used herb pairs and combinations was found, 7 new prescriptions were clustered. Conclusion Treatment of MPE includes warming yang for resolving fluid retention, clearing heat and removing toxicity, activating qi and promoting blood circulation, and benefiting qi and diuresis. Taking care of the spleen and stomach is an important idea for treating MPE. The core of MPE treatment is to combinate classical prescriptions and astragalus following syndrome differentiation.
|
|
|
|
|
|
[1] Psallidas I，Kalomenidis I，Porcel JM，et al. Malignant pleural effusion：from bench to bedside [J]. Eur Respir Rev，2016，25（140）：189-198.
[2] Walker S，Mercer R，Maskell N，et al. Malignant pleural effusion management：keeping the flood gates shut [J]. Lancet Respir Med，2019.[Epub ahead of print]
[3] Guinde J，Georges S，Bourinet，et al. Recent developments in pleurodesis for malignant pleural disease [J]. Clin Respir J，2018，12（10）：2463-2468.
[4] Penz E，Watt KN，Hergott CA，et al. Management of malignant pleural effusion：challenges and solutions [J]. Cancer Manag Res，2017，9：229-241.
[5] Bibby AC，Dorn P，Psallidas I，et al. ERS/EACTS statement on the management of malignant pleural effusions [J]. Eur J Cardiothorac Surg，2019，55（1）：116-132.
[6] Asciak R，Rahman NM. Malignant pleural effusion：from diagnostics to therapeutics [J]. Clin Chest Med，2018，39（1）：181-193.
[7] 金志超，施展，花宝金.中医药防治恶性胸腔积液的研究评述[J].中华中医药杂志，2017，32（8）：3339-3341.
[8] 齐雪维.温阳化饮法治疗恶性胸腔积液的Meta分析及定性研究[D].北京：北京中医药大学，2019.
[9] 国家药典委员会.中华人民共和国药典[M].一部.北京：中国中医药科技出版社，2015.
[10] 钟赣生.中药学[M].10版.北京：中国中医药出版社，2018.
[11] 龙婧，郑琪，马婕群，等.恶性胸腔积液治疗的研究进展[J].医学综述，2019，25（3）：470-474.
[12] 李士瑾，冯志海.清肺固金汤合苇茎汤治疗肺癌并发恶性胸腔积液的临床研究[J].时珍国医国药，2018，29（10）：2435-2437.
[13] 姚菲，荣震，石玮，等.从太阴及少阴病角度试探恶性胸腔积液的发病机制及治疗[J].中医药导报，2018，24（19）：35-37.
[14] 吕明圣，晏军.理肺健脾活血利水法治疗悬饮一例[J].环球中医药，2018，11（10）：1573-1574.
[15] 施展，花宝金，鲍艳举.花宝金教授辨治恶性胸腔积液经验[J].中华中医药杂志，2014，29（5）：1518-1520.
[16] 叶霈智，冯利，秦子舒，等.木防己汤加减治疗癌性胸腔积液[J].中医杂志，2018，59（3）：251-253.
[17] 史佩玉，林樫，陈国铭，等.基于网络药理学的葶苈子潜在作用机制研究[J].中国药房，2019，30（20）：2823-2828.
[18] 岳美颖.茯苓主要药理作用及临床应用[J].亚太传统医药，2016，12（7）：68-69.
[19] Jiao R，Liu Y，Gao H，et al. The anti-oxidant and antitumor properties of plant polysaccharides [J]. Am J Chin Med，2016，44（3）：463-488.
[20] 张利青，张占刚，付岩，等.桂皮醛药理作用的研究进展[J].中国中药杂志，2015，40（23）：4568-4572.
[21] 张晓娟，左冬冬.白术化学成分及药理作用研究新进展[J].中医药信息，2018，35（6）：101-106.
[22] 丁晨曦，刘林涛，方志军，等.经方在治疗肿瘤相关并发症的应用及研究进展[J].山东中医药大学学报，2018， 42（6）：561-564.
[23] 唐仕欢，申丹，卢朋，等.中医传承辅助平台应用评述[J].中华中医药杂志，2015，30（2）：329-331. |
|
|
|
