COPD合并呼吸衰竭患者预后因素分析及SP-A和SP-D检测对其预后的评估价值

Abstract
Figure/Table
References (22)
Related Citation (15)

Download: PDF (648 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the significance of serum surfactant protein A (SP-A) and surfactant protein D (SP-D) in patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure and their prognostic value. Methods A total of 70 COPD patients hospitalized in the Department of Respiratory Medicine of Qinghai Provincial People′s Hospital from September 2015 to August 2018 were selected. They were divided into COPD group (20 cases), combined with type Ⅰ respiratory failure group (25 cases) and combined with type Ⅱ respiratory failure group (25 cases), according to the presence or absence of respiratory failure. The laboratory indicators and blood gas indicators of each group were analyzed. According to the outcome indexes of COPD patients with respiratory failure, they were divided into death group (13 cases) and non-death group (37 cases), while the prognostic risk factors were analyzed. Results The C-reactive protein of the combined type Ⅰ and type Ⅱ respiratory failure groups were lower than that of the COPD group, while SP-A and SP-D were higher than those of the COPD group, and the differences were statistically significant (P ＜ 0.05). The pH of the combined type Ⅱ respiratory failure group was lower than that of the COPD group, and the difference was statistically significant (P ＜ 0.05). The partial pressure of oxygen in the combined type Ⅰ and type Ⅱ respiratory failure group were lower than that in the COPD group, while combined type Ⅱ respiratory failure group was higher than combined type Ⅰ respiratory failure group, and the differences were statistically significant (P ＜ 0.05). The partial pressure of carbon dioxide in the combined with type Ⅱ respiratory failure group was higher than those in the COPD group and the combined typeⅠrespiratory failure group, and the differences were statistically significant (P ＜ 0.05). There were statistically significant differences between the death group and non-death group in smoking, pH, SP-A and SP-D (P ＜ 0.05). Logistic regression analysis showed that pH was a risk factor for the prognosis of COPD combined with respiratory failure (OR ＞ 1, P ＜ 0.05). Conclusion In COPD patients with respiratory failure, SP-A and SP-D increased, and of little assessed value in the prognosis of COPD combined with respiratory failure, while pH has a greater assessed value of COPD combined with respiratory failure.

Key words： Chronic obstructive pulmonary disease Respiratory failure Surfactant Protein Prognosis Risk factors

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	GU Yuhai1 SHI Xuefengu1 NIU Di2 XIE Youbang3

Cite this article:

GU Yuhai1 SHI Xuefengu1 NIU Di2 XIE Youbang3. Analysis of prognostic risk factors and the prognostic assessed value of SP-A and SP-D in COPD with respiratory failure patients[J]. 中国医药导报, 2020, 17(14): 135-139.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I14/135

[1] Pizarro C，Skowasch D. Comorbidities in Chronic Obstructive Pulmonary Disease [J]. Dtsch Med Wochenschr，2019， 144（1）：28-33.
[2] Papaioannou AI，Kostikas K，Manali ED，et al. Serum Levels of Surfactant Proteins in Patients with Combined Pulmonary Fibrosis and Emphysema（CPFE）[J]. PloS One，2016，11（6）：e0157789.
[3] Vlachaki EM，Koutsopoulos AV，Tzanakis N，et al. Altered surfactant protein-A expression in type Ⅱ pneumocytes in COPD [J]. Chest，2010，137（1）：37-45.
[4] Sims MW，Tal-Singer RM，Kierstein S，et al. Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D（SP-D）levels：a cross-sectional study [J]. Respir Res，2008，9：13.
[5] Bartsch F，Tripke V，Baumgart J，et al. Extended resection of intrahepatic cholangiocarcinoma：A retrospective single-center cohort study [J]. Int J Surg，2019，67：62-69.
[6] Ho T，Cusack RP，Chaudhary N，et al. Under- and over-diagnosis of COPD：a global perspective [J]. Breathe，2019， 15（1）：24-35.
[7] Trethewey SP，Edgar RG，Morlet J，et al. Temporal trends in survival following ward-based NIV for acute hypercapnic respiratory failure in patients with COPD [J]. Clin Respir J，2019，13（3）：184-188.
[8] Lin X，Wu Z，Fan Y，et al. Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD [J]. Mol Med Rep，2017，16（4）：4948-4954.
[9] Larstad M，Almstrand AC，Larsson P，et al. Surfactant Protein A in Exhaled Endogenous Particles Is Decreased in Chronic Obstructive Pulmonary Disease（COPD）Patients：A Pilot Study [J]. PLoS One，2015，10（12）：e0144463.
[10] Nida，Lone KP. Plasma surfactant protein-A levels in apparently healthy smokers，stable and exacerbation COPD patients [J]. Pak J Med Sci，2018，34（4）：934-939.
[11] Lin XF，Zhang L，Shi SY，et al. Expression of surfactant protein-A in exhaled breath condensate of patients with chronic obstructive pulmonary disease [J]. Mol Med Rep，2016，13（2）：1667-1672.
[12] Iwamoto H，Gao J，Koskela J，et al. Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap [J]. Eur Respir J，2014，43（2）：421-429.
[13] Ishikawa N，Hattori N，Tanaka S，et al. Levels of surfactant proteins A and D and KL-6 are elevated in the induced sputum of chronic obstructive pulmonary disease patients：a sequential sputum analysis [J]. Respiration，2011，82（1）：10-18.
[14] Behera D，Balamugesh T，Venkateswarlu D，et al. Serum surfactant protein-A levels in chronic bronchitis and its relation to smoking [J]. Indian J Chest Dis Allied Sci，2005，47（1）：13-17.
[15] Sorensen GL. Surfactant Protein D in Respiratory and Non-Respiratory Diseases [J]. Front Med，2018，5：18.
[16] Crisafulli E，Ielpo A，Barbeta E，et al. Clinical variables predicting the risk of a hospital stay for longer than 7 days in patients with severe acute exacerbations of chronic obstructive pulmonary disease：a prospective study [J]. Respir Res，2018，19（1）：261.
[17] Wong EKC，Lee PCS，Ansary S，et al. Role of venous blood gases in hypercapnic respiratory failure chronic obstructive pulmonary disease patients presenting to the emergency department [J]. Inter Med J，2019，49（7）：834-837.
[18] Raveling T，Bladder G，Vonk JM，et al. Improvement in hypercapnia does not predict survival in COPD patients on chronic noninvasive ventilation [J]. Int J Chron Obstruct Pulmon Dis，2018，13：3625-3364.
[19] Crisafulli E，Barbeta E，Ielpo A，et al. Management of severe acute exacerbations of COPD：an updated narrative review [J]. Multidis Respir Med，2018，13：36.
[20] Beghe B，Fabbri LM，Garofalo M，et al. Three-Year Hospitalization and Mortality in Elderly Smokers with Chronic Obstructive Pulmonary Disease or Chronic Heart Failure [J]. Respiration，2019，97（3）：223-233.
[21] Fazekas AS，Aboulghaith M，Kriz RC，et al. Long-term outcomes after acute hypercapnic COPD exacerbation：First-ever episode of non-invasive ventilation [J]. Wien Klin Wochenschr，2018，130（19/20）：561-568.
[22] Ceriana P，Vitacca M，Carlucci A，et al. Changes of Respiratory Mechanics in COPD Patients from Stable State to Acute Exacerbations with Respiratory Failure [J]. COPD， 2017，14（2）：150-155.