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| Diagnostic accuracy of breath test in detection of delayed gastric emptying: a meta-analysis |
| BAI Ying1 GAO Wei2 CONG Jialin2 CHENG Shuli2 ZHAO Xingjie3 ZHANG Li4 YANG Xiaohui5,6 |
1.College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
2.the Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100078, China;
3.Department of Gastroenterology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China;
4.Department of Endocrinology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China;
5.Department of Endocrinology, Dongzhimeng Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;
6.Traditional Chinese Medicine Master LYU Heren Work Station at Dongfang Hospital Affilated to Beijing University of Chinese Medicine, Beijing 100078, China |
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Abstract Objective To evaluate the diagnostic value of breath test for delayed gastric emptying. Methods Database include PubMed, the Cochrane Library, China National Knowledge Internet, WanFang Data, VIP, CBM were searched to collect exsiting diagnostic accuracy tests on delayed gastric emptying diagnosed, the retrieval time was from database construction to April 2018. The fixed effect model was used for meta-analysis, and the research indicators included sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and the area under the curve (AUC). Results Ten studies with 434 objects were included. The sensitivity of breath test for diagnosis of delayed gastric emptying was 0.826 (95%CI: 0.728 to 0.894), and the specificity was 0.876 (95%CI: 0.800 to 0.925). The AUC was 0.92. The combined positive likelihood ratio was 6.640 (95%CI: 3.987 to 11.060), and the negative likelihood ratio was 0.198 (95%CI: 0.122 to 0.321). Conclusion Breath test is a useful tool for detecting delayed gastric emptying with a relatively high sensitivity and specificity. It is expected to be applied in clinic.
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[1] Camilleri M，Parkman HP，Shafi MA，et al. Clinical guideline： management of gastroparesis [J]. Am J Gastroenterol. 2013，108（1）：18-37.
[2] Dibaise JK，Patel N，Noelting J，et al. The relationship among gastroparetic symptoms，quality of life，and gastric emptying in patients referred for gastric emptying testing [J]. Neurogastroenterol Motil，2016，28（2）：234-242.
[3] 徐菁菁，曹忠耀，范志勇，等.高血糖与糖尿病胃轻瘫发生机制的研究现状[J].中国中西医结合消化杂志，2011， 19（5）：338-341.
[4] Zhao X，Mashimo H. Current and Emerging Medical Therapies for Gastroparesis [J]. Curr Treat Options Gastroenterol，2015，13（4）：452-72.
[5] Bestetti A，Capozza A，Lacerenza M，et al. Delayed Gastric Emptying in Advanced Parkinson Disease：Correlation with Therapeutic Doses [J]. Clin Nucl Med，2017，42（2）：83-87.
[6] Nojiri M，Yukihiro Y，Takashi M，et al. Impact of the gastrojejunal anatomic position as the mechanism of delayed gastric emptying after pancreatoduodenectomy [J]. Surgery，2018，163（5）：1063-1070.
[7] Hanjay W，Adam D，Ronald F，et al. Delayed gastric emptying after living donor hepatectomy for liver transplantation [J]. Case Rep Transplant，2014，2014：582183.
[8] Abell TL，Camilleri M，Donohoe K，et al. Consensus Recommendations for Gastric Emptying Scintigraphy：A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine [J]. Am J Gastroenterol，2008，103（3）：753-763.
[9] Hejazi RA，Sarosiek I，Roeser K，et al. Does grading the severity of gastroparesis based on scintigraphic gastric emptying predict the treatment outcome of patients with gastroparesis? [J]. Digest Dis Sci，2011，56（4）：1147-1153.
[10] Pathikonda M，Sachdeva P，Malhotra N，et al. Gastric emptying scintigraphy：is four hours necessary? [J]. J Clin Gastroenterol，2012，46（3）：209-215.
[11] Surdea-Blaga T，David L，Dumitrascu DL. The Use of Breath Test for the Assessment of Gastric Emptying Rate in Clinical Practice [A]. International Conference on Advancements of Medicine and Health Care through Technology; 5th-7th June 2014，Cluj-Napoca，Romania. Springer International Publishing，2014：53-56.
[12] Ghoos YF，Maes BD，Geypens BJ，et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test [J]. Gastroenterology，1993，104（6）：1640-1647.
[13] Barzakova Emona S，Schulze-Hagen M，Zimmermann M，et al. Monitoring Liver Function of Patients Undergoing Transarterial Chemoembolization （TACE） by a 13C Breath Test （LiMAx）[J]. Cardiovasc Inter Rad，2019，42（12）：1702-1708.
[14] Leonilde B，Ignazio G，Giuseppe P，et al. Dynamic carbon 13 breath tests for the study of liver function and gastric emptying [J]. Gastroenterol Rep，2014，3（1）：12-21.
[15] 王莎莎，王永席，翟红兵，等.13C-辛酸呼气试验对反流性食管炎患者胃排空功能的检测[J].中国中西医结合消化杂志，2011，19（4）：247-248.
[16] Parkman HP. Assessment of gastric emptying and small-bowel motility：scintigraphy，breath tests，manometry，and Smart Pill [J]. Gastrointest Endosc Clin N Am，2009，19（1）：49-55.
[17] Navas CM，Patel NK，Lacy BE. Gastroparesis：Medical and Therapeutic Advances [J]. Dig Dis Sci，2017，62（9）：2231-2240.
[18] Choi MG，Camilleri M，Burton DD，et al. [13C] octanoic acid breath test for gastric emptying of solids: Accuracy，reproducibility，and comparison with scintigraphy [J]. Gastroenterology，1997，112（4）：1155-1162.
[19] Ghoos YF，Maes BD，Geypens BJ，et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test [J]. Gastroenterology，1993， 104（6）：1640-1647.
[20] Sanaka M，Yamamoto T，Kuyama Y. Theoretical flaws in gastric emptying breath test：Why is it dubious? [J]. Dig Dis Sci，2005，50（1）：15-17.
[21] Szarka LA，Camilleri M，Vella A，et al. A Stable Isotope Breath Test with a Standard Meal for Abnormal Gastric Emptying of Solids in the Clinic and in Research [J]. Clin Gastroenterol H，2008，6（6）：635.
[22] Bromer MQ，Kantor SB，Wagner DA，et al. Simultaneous Measurement of Gastric Emptying with a Simple Muffin Meal Using [13C] Octanoate Breath Test and Scintigraphy in Normal Subjects and Patients with Dyspeptic Symptoms [J]. Dig Dis Sci，2002，47（7）：1657-1663.
[23] Dickman R，Steinmetz A，Bernnstine H，et al. A novel continuous breath test versus scintigraphy for gastric emptying rate measurement [J]. J Clin Gastroenterol，2011，45（1）：22-25.
[24] Dickman R，Zilper T，Steinmetz A，et al. Comparison of continuous breath test and gastric scintigraphy for the measurement of gastric emptying rate in healthy and dyspeptic individuals [J]. Eur J Gastroen Hepat，2013，25（3）：291-295.
[25] Chapman MJ，Besanko LK，Burgstad CM，et al. Gastric emptying of a liquid nutrient meal in the critically ill： relationship between scintigraphic and carbon breath test measurement [J]. Gut，2011，60（10）：1336-1343.
[26] Pfaffenbach B，Wegener M，Adamek RJ，et al. Non-invasive 13C octanoic acid breath test for measuring stomach emptying of a solid test meal--correlation with scintigraphy in diabetic patients and reproducibility in healthy probands [J]. Z Gastroenterol，1995，33（3）：141.
[27] Ziegler D，Schadewaldt P，Pour MA，et al. [13C] octanoic acid breath test for non-invasive assessment of gastric emptying in diabetic patients： validation and relationship to gastric symptoms and cardiovascular autonomic function [J]. Diabetologia，1996，39（7）：823.
[28] Delbende B，Perri FO，Leodolter A，et al. 13C-octanoic acid breath test for gastric emptying measurement [J]. Eur J Gastroenterol Hepatol，2000，12（1）：85-91.
[29] Nastou D，Owen E，Jaboli FM，et al. PTU-146 The Trinity of Gastric Emptying Scintigraphy，13C Acetate Gastric Emptying Breath Testing，and Real Time Gastric Ultrasonography Indicates High Prevalence of Gastric Motor Dysfunction In Functional Dyspepsia [J]. Gastroenterology，2014，63（Suppl 1）：A102-A103.
[30] Sanaka M，Nakada K，Nosaka C，et al. The Wagner-Nelson method makes the [13C]-breath test comparable to radioscintigraphy in measuring gastric emptying of a solid/liquid mixed meal in humans [J]. Clin Exp Pharmacol Physiol，2007，34（7）：641-644. |
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