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| Analysis of sialic acid levels in patients with senile pulmonary disease |
| LIU Pei WU Guoyou ZHANG Yapei DONG Shilei |
| Department of Clinical Laboratory, Zhejiang Hospital, Zhejiang Province, Hangzhou 310000, China |
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Abstract Objective To explore the changes of sialic acid (SA) in serum of elderly patients with chronic obstructive pulmonary disease (COPD), pneumonia and lung cancer. Methods A total of 274 elderly patients admitted to Zhejiang Hospital (“our hospital” for short) from December 2017 to December 2018 were selected as the observation group. According to the diagnostic criteria of three diseases, laboratory examination and imaging examination, they were divided into the following three groups: COPD group (74 cases), pneumonia group (100 cases), lung cancer group (100 cases). A total of 100 healthy people who were examined during the same period were used as the control group. The SA kit was used to detect the SA content in serum samples from patients, while the correlation between lung diseases and sialic acid changes were analyzed. Results Compared with the control group, serum SA levels in COPD group, pneumonia group and lung cancer group were all increased, and the differences were all statistically significant (all P ＜ 0.05). Serum SA levels in the pneumonia group and the lung cancer group were higher than those in the COPD group, with statistically significant differences (P ＜ 0.05). There was no statistically significant difference in serum SA level between the pneumonia group and the lung cancer group (P ＞ 0.05). Pearson correlation analysis showed that serum SA level in COPD group was negatively correlated with that in lung cancer group (r = -0.25, P ＜ 0.05). Conclusion The use of enzymatic detection of sialic acid in serum not only provides initial clinical diagnostic value for patients with chronic lung disease, but also provides a certain auxiliary effect for targeted therapy of disease.
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