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| Expression of lncRNA-GAS5 and its clinical significance in nasopharyngeal carcinoma |
| LUO Haiqing JIANG Danxian YANG Donghong CHEN Zhenglu ZHONG Yu′nan CHEN Zihong YU Zhonghua |
| Nasopharyngeal Carcinoma Area, Affiliated Hospital of Guangdong Medical University, Guangdong Province, Zhanjiang 524001, China |
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Abstract Objective To investigate the expression of long non-coding RNA-growth arrest-specific 5 (lncRNA-GAS5) in nasopharyngeal carcinoma and to evaluate its clinical significance． Methods From March 2013 and December 2018, 56 cases with nasopharyngeal carcinoma tissue samples from Affiliated Hospital of Guangdong Medical University were collected as nasopharyngeal carcinoma group, and 42 cases of normal nasopharyngeal tissue samples were collected as control group. The expression of lncRNA-GAS5 was detected by qRT-PCR. The correlations between the expression of lncRNA-GAS5 and pathological characteristics and prognostic were analyzed. Results The relative expression of lncRNA-GAS5 in nasopharyngeal carcinoma group was lower than that in control group, and the difference was statistically significant (P < 0.05). TNM stage, lymph node metastasis and tumor differentiation were closely related to the expression level of lncRNA-GAS5 (P < 0.05). The survival of patients with high expression of lncRNA-GAS5 was significantly higher than patients with low expression (P < 0.01). Conclusion The expression of lncRNA-GAS5 is down-regulated in nasopharyngeal carcinoma tissues and may serve as a potential new prognostic for nasopharyngeal carcinoma．
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