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| Clinical effect of Tigapine and Cisplatin combined with Docetaxel in the treatment of cervical cancer |
| LI Jinwu1 HU Shan2 LIU Yanyun3 XU Hai3 |
1.Department of Pharmacy, Huanggang Maternal and Child Health Hospital, Hubei Province, Huanggang 430080, China;
2.Department of Gynecology and Obstetrics, Wuhan Union Hospital, Hubei Province, Wuhan 430022, China;
3.School of Basic Medicine of Hubei University of Traditional Chinese Medicine, Hubei Province, Wuhan 430070, China |
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Abstract Objective To observe the clinical effect of Tigapine, Cisplatin and Docetaxel in the treatment of cervical cancer and to explore the possible mechanism of action. Methods From June 2017 to January 2019, 112 cases with cervical cancer who admitted to Wuhan Union Hospital of Hubei Province were selected. According to random number table method, they were divided into control group and observation group, with 56 cases in each group. Control group was treated with Tigapine combined with Cisplatin and observation group was treated with Docetaxel on the basis of control group. The clinical efficacy of the two groups, and changes in serum tumor markers, Th1/Th2 cytokine content and immune function level was compared the adverse reactions during medication was recorded. Results The disease control rate and the objective remission rate of observation group were higher than those of control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of carcino-embryonic antigen, carbohydrate antigen 19-9 (CA19-9), CA125 and squamous cell carcinoma antigen in two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (all P < 0.05). After treatment, the levels of γ interferon (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) in observation group were higher than those before treatment, and the levels of IL-4, IL-6 and IL-10 were lower than those before treatment; and the levels of IFN-γ, TNF-α and IL-2 in observation group were higher than those in control group, and the levels of IL-4, IL-6, and IL-10 in observation group were lower than those in control group, with statistically significant differences (all P < 0.05). The incidence of adverse reactions during treatment in two groups was statistically significant (P < 0.05). Conclusion The clinical effect of Docetaxel and Tigapine combined with Cisplatin in the treatment of advanced cervical cancer is definite, which is conducive to reducing the level of serum tumor markers, correcting the immune imbalance of Th1/Th2 cells and reducing adverse reactions, which is worthy of clinical promotion.
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