lncRNA与胃癌临床特征相关性的meta分析

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Abstract Objective To study the correlation between long non-coding RNA (lncRNA) and gastric cancer and prognosis. Methods PubMed, EMbase and Web of Science database were searched, the search ended on April 2019. According to the retrieval strategy and inclusion and exclusion criteria, the literatures were screened and the relevant data were extracted. Stata software was used for meta analysis. Results Eighteen literatures were included in this study. The risk of gastric cancer in the group with high expression of lncRNA was 1.510 times than that of the group with low expression of lncRNA (HR = 1.510, 95%CI: 1.213-1.878, P = 0.000). Meta-analysis showed that there was publication bias in the literature. LncRNA expression level and TNM stage of gastric cancer patients (HR = 1.981, 95%CI: 1.458-2.692, P = 0.000), tumor differentiation degree (HR = 1.273, 95%CI: 1.103-1.469, P = 0.001), invasion depth (HR = 1.862, 95%CI: 1.565-2.216, P = 0.000), lymph node metastasis (HR = 1.570, 95%CI: 1.086-2.270, P = 0.016), and distant metastasis (HR = 2.581, 95%CI: 1.503-4.430, P = 0.001) were significantly correlated. Conclusion lncRNA is associated with poor prognosis and clinicopathological features in patients with gastric cancer, so it may be an important biomarker for gastric cancer patients. However, its clinical application still needs to be verified through more researches in the future.

Key words： Long non-coding RNA Gastric cancer Prognosis Clinical features Meta-analysis

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	Articles by authors
	LI Fan1
	2 WANG Yuping1
	2 CHEN Zhaofeng1
	2 GUO Qinghong1
	2 GUAN Quanlin3 ZHOU Yongning1
	2

Cite this article:

LI Fan1,2 WANG Yuping1,2 CHEN Zhaofeng1, et al. Meta analysis of the relationship between the lncRNA and clinical features of gastric cancer[J]. 中国医药导报, 2020, 17(14): 90-93,105.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I14/90

[1] Siegel RL，Miller KD，Jemal A. Cancer Statistics，2017 [J]. CA-Cancer J Clin，2017，67（1）：7-30.
[2] Zoalfaghari A，Aletaha N，Roushan N，et al. Accuracy of pepsinogens for early diagnosis of atrophic gastritis and gastric cancer in Iranian population [J]. Med J Islam Repub Iran，2014，28：150.
[3] Wang X. Down-regulation of lncRNA-NEAT1 alleviated the non-alcoholic fatty liver disease via mTOR/S6K1 signaling pathway [J]. J Cell Biochem，2018，119（2）：1567-1574.
[4] Huang GW，Xue YJ，Wu ZY，et al. A three-lncRNA signature predicts overall survival and disease-free survival in patients with esophageal squamous cell carcinoma [J]. BMC Cancer，2018，18（1）：147.
[5] Mathy NW，Chen XM. Long non-coding RNAs （lncRNAs） and their transcriptional control of inflammatory responses [J]. J Biol Chem，2017，292（30）：12375-12382.
[6] Iguchi T，Uchi R，Nambara S，et al. A long noncoding RNA，lncRNA-ATB，is involved in the progression and prognosis of colorectal cancer [J]. Anticancer Res，2015，35（3）：1385-1388.
[7] Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses [J]. Eur J Epidemiol，2010：25（9）：603-695.
[8] Chen X，Sun J，Song Y，et al. The novel long noncoding RNA AC138128.1 may be a predictive biomarker in gastric cancer [J]. Med Oncol，2014，31（11）：262.
[9] Zhang EB，Han L，Yin DD，et al. c-Myc-induced，long，noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer [J]. Med Oncol，2014，31（5）：914.
[10] Zheng Q，Wu F，Dai WY，et al. Aberrant expression of UCA1 in gastric cancer and its clinical significance [J]. Clin Transl Oncol，2015，17（8）：640-646.
[11] Wang CY，Hua L，Yao KH，et al. Long non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis [J]. Int J Clin Exp Pathol，2015，8（1）：779-785.
[12] Li L，Zhang L，Zhang Y，et al. Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer [J]. Biomed Pharmacother，2015，72：109-112.
[13] Chen WM，Huang MD，Kong R，et al. Antisense Long Noncoding RNA HIF1A-AS2 Is Upregulated in Gastric Cancer and Associated with Poor Prognosis [J]. Dig Dis Sci，2015，60（6）：1655-1662.
[14] Zhang Y，Yang R，Lian J，et al. LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer [J]. Am J Transl Res，2016，8（11）：5035-5043.
[15] Zhang E，Yin D，Han L，et al. E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs [J]. Oncotarget，2016，7（17）：23212-23226.
[16] Ma P，Xu T，Huang M，et al. Increased expression of LncRNA PANDAR predicts a poor prognosis in gastric cancer [J]. Biomed Pharmacother，2016，78：172-176.
[17] Yuan CL，Li H，Zhu L，et al. Aberrant expression of long noncoding RNA PVT1 and its diagnostic and prognostic significance in patients with gastric cancer [J]. Neoplasma，2016，63（3）：442-449.
[18] Cui WC，Wu YF，Qu HM. Up-regulation of long non-coding RNA PCAT-1 correlates with tumor progression and poor prognosis in gastric cancer [J]. Eur Rev Med Pharmacol Sci，2017，21（13）：3021-3027.
[19] Zhang W，Song Y. LINC00473 predicts poor prognosis and regulates cell migration and invasion in gastric cancer [J]. Biomed Pharmacother，2018，107：1-6.
[20] Zhang MH，Yang Y，Zhao Y，et al. LncRNA DQ786243 expression as a biomarker for assessing prognosis in patients with gastric cancer [J]. Eur Rev Med Pharmacol Sci，2018，22（8）：2304-2309.
[21] Wang Z，Qin B. Prognostic and clinicopathological significance of long noncoding RNA CTD-2510F5.4 in gastric cancer [J]. Gastric Cancer，2019，22（4）：692-704.
[22] Chong DQ，Shan JL，Yang CS，et al. Clinical prognostic value of A FOXM1 related long non-coding RNA expression in gastric cancer [J]. Eur Rev Med Pharmacol Sci，2018，22（2）：417-421.
[23] Zhang JF，Jiang W，Zhang QF，et al. Long noncoding RNA STCAT16 suppresses cell growth and its downregulation is significantly associated with poor survival in gastric cancer patients [J]. Mol Med Rep，2019，19（6）：4613-4622.
[24] Chen CL，Ke Q，Luo M，et al. Loss of LINC01939 expression predicts progression and poor survival in gastric cancer [J]. Pathol Res Pract，2018，214（10）：1539-1543.
[25] Wang W，Song ZJ，Wang Y，et al. Elevated long non-coding RNA LINC00958 was associated with metastasis and unfavorable prognosis in gastric cancer [J]. Eur Rev Med Pharmacol Sci，2019，23（2）：598-603.
[26] 曹毛毛，陈万青.中国恶性肿瘤流行情况及防控现状[J].中国肿瘤临床，2019，46（3）：145-149.
[27] UA ?覫，Shiekhattar R. Long non-coding RNAs and enhancers [J]. Curr Opin Genet Dev，2011，21（2）：194-198.
[28] 郑斌，王宇.长链非编码RNA UCA1在消化系统肿瘤中的研究进展[J].中国肿瘤，2018，27（3）：209-213.
[29] Yang F，Bi J，Xue X，et al. Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells [J]. FEBS J，2012，279（17）：3159-3165.
[30] Liu XH，Sun M，Nie FQ，et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer [J]. Mol Cancer，2014，13：92.